D'Emanuele A, Hill J, Tamada J A, Domb A J, Langer R
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge 02139.
Pharm Res. 1992 Oct;9(10):1279-83. doi: 10.1023/a:1015801216466.
We report a study of the effects of polymer molecular weight on the erosion of polyanhydride copolymer matrices composed of 1,3-bis(p-carboxyphenoxy)-propane (CPP) and sebacic acid (SA) in aqueous solution. The erosion profile characteristically displays an induction period during which the erosion rate is relatively slow. The length of this period depends on the initial molecular weight of the polymer. The induction period may be characterized as a time during which a rapid decrease in polymer molecular weight occurs, the end of this period correlating with the time required for the polymer molecular weight to decrease to below a value of approximately 5000 (MW).
我们报告了一项关于聚合物分子量对由1,3-双（对羧基苯氧基）丙烷（CPP）和癸二酸（SA）组成的聚酸酐共聚物基质在水溶液中侵蚀作用影响的研究。侵蚀曲线的特征是显示出一个诱导期，在此期间侵蚀速率相对较慢。这个时期的长短取决于聚合物的初始分子量。诱导期可被描述为聚合物分子量迅速下降的时期，这个时期的结束与聚合物分子量下降到大约5000（MW）以下所需的时间相关。
