Geraili Armin, Mequanint Kibret
School of Biomedical Engineering, The University of Western Ontario, London, ON N6A 5B9, Canada.
Department of Chemical and Biochemical Engineering, The University of Western Ontario, London, ON N6A 5B9, Canada.
Polymers (Basel). 2020 May 12;12(5):1105. doi: 10.3390/polym12051105.
Photocrosslinkable polyanhydrides that undergo surface erosion are suitable materials for controlled-release drug delivery systems. Investigating the impact of different parameters on their erosion behavior is essential before use in drug delivery systems. Although their synthesis is well-established, parameters that may substantially affect the erosion of thiol-ene polyanhydrides including temperature and pH of the media, the geometry of the polymers, and the media shaking rate (the convective force for the polymer erosion), have not yet been studied. This study explores the effects of different environmental and geometric parameters on mass loss (erosion) profiles of polyanhydrides synthesized by thiol-ene photopolymerization. A comparative study on several release kinetic models fitting is also described for a better understanding of the polymer erosion behavior. The results demonstrated that although the temperature was the only parameter that affected the induction period substantially, the mass-loss rate was influenced by the polymer composition, tablet geometry, temperature, pH, and mass transfer (shaking) rate. With regard to geometrical parameters, polymers with the same surface area to volume ratios showed similar mass loss trends despite their various volumes and surface areas. The mass loss of polyanhydride tablets with more complicated geometries than a simple slab was shown to be non-linear, and the kinetic model study indicated the dominant surface erosion mechanism. The results of this study allow for designing and manufacturing efficient delivery systems with a high-predictable drug release required in precision medicine using surface-erodible polyanhydrides.
可光交联且发生表面侵蚀的聚酸酐是用于控释给药系统的合适材料。在用于给药系统之前，研究不同参数对其侵蚀行为的影响至关重要。尽管它们的合成方法已成熟，但可能会显著影响硫醇-烯聚酸酐侵蚀的参数，包括介质的温度和pH值、聚合物的几何形状以及介质振荡速率（聚合物侵蚀的对流力），尚未得到研究。本研究探讨了不同环境和几何参数对通过硫醇-烯光聚合合成的聚酸酐质量损失（侵蚀）曲线的影响。还描述了对几种释放动力学模型拟合的比较研究，以更好地理解聚合物的侵蚀行为。结果表明，虽然温度是唯一对诱导期有显著影响的参数，但质量损失率受聚合物组成、片剂几何形状、温度、pH值和传质（振荡）速率的影响。关于几何参数，具有相同表面积与体积比的聚合物，尽管其体积和表面积各不相同，但显示出相似的质量损失趋势。几何形状比简单平板更复杂的聚酸酐片剂的质量损失呈非线性，动力学模型研究表明主要是表面侵蚀机制。本研究结果有助于设计和制造高效给药系统，在精准医学中使用可表面侵蚀的聚酸酐实现高度可预测的药物释放。
