大鼠食物摄入量、体重及转轮活动对卵巢甾体激素敏感性的性别差异。

Sex differences in sensitivity of food intake, body weight, and running-wheel activity to ovarian steroids in rats.

作者信息

Gentry R T, Wade G N

出版信息

J Comp Physiol Psychol. 1976 Aug;90(8):747-54. doi: 10.1037/h0077246.

Abstract

The effects of sex and experimental androgenization on the responsiveness of food intake and running-wheel activity to exogenously administered ovarian hormones were investigated in adult, gonadectomized rats. Food intake was found to be analogous to lordotic behavior in that males and neonatally androgenized females were relatively insensitive to the influences of either estradiol benzoate (EB) or progesterone (P). Running-wheel activity, however, could be differentiated from food intake in that males responded the same as females to the effects of EB and P. Androgenized females (500-mug testosterone propionate on the third day of life) showed a response to EB quantitatively equivalent to that of nonandrogenized females, but they had a longer latency to respond. The estrogen-antagonistic effects of P were confirmed for both of these behaviors, and there was a positive correlation between the magnitude of the responses to EB and P.

摘要

在成年去势大鼠中，研究了性别和实验性雄激素化对外源性给予卵巢激素时食物摄入量和转轮活动反应性的影响。发现食物摄入量与脊柱前凸行为类似，即雄性和新生期雄激素化的雌性对苯甲酸雌二醇（EB）或孕酮（P）的影响相对不敏感。然而，转轮活动与食物摄入量有所不同，雄性对EB和P的反应与雌性相同。雄激素化的雌性（出生第三天注射500微克丙酸睾酮）对EB的反应在数量上与未雄激素化的雌性相当，但反应潜伏期更长。P对这两种行为的雌激素拮抗作用得到证实，并且对EB和P的反应强度之间存在正相关。