Donohoe T P, Stevens R
Physiol Behav. 1983 Sep;31(3):325-9. doi: 10.1016/0031-9384(83)90196-8.
Body weights and skeletal growth of female rats treated neonatally with low doses of testosterone propionate (TP) or estradiol benzoate (FB) were greater than oil-treated controls. After ovariectomy at 75 days of age EB-treated animals gained less weight than did the oil-treated controls and TP-treated rats which were comparable in weight gain. Neonatal treatment with TP or EB produced decreased sensitivity to the anorexic and weight-limiting effects of estrogen treatment after ovariectomy. However, all groups were equally sensitive to the anorexic effects of a single dose of CI-628. The possible mechanisms by which neonatal treatments with gonadal hormones influence food intake and body weight regulation are discussed.
新生期用低剂量丙酸睾酮（TP）或苯甲酸雌二醇（EB）处理的雌性大鼠的体重和骨骼生长大于用油处理的对照。75日龄卵巢切除术后，接受EB处理的动物体重增加比用油处理的对照以及体重增加相当的TP处理大鼠少。新生期用TP或EB处理使卵巢切除术后对雌激素处理的厌食和体重限制作用的敏感性降低。然而，所有组对单剂量CI - 628的厌食作用同样敏感。讨论了性腺激素新生期处理影响食物摄入和体重调节的可能机制。
