Afenya E K, Bentil D E
Department of Mathematics, Elmhurst College, IL 60126, USA.
Math Biosci. 1998 Jun 15;150(2):113-30. doi: 10.1016/s0025-5564(98)10005-6.
A diffusion model of leukemia is presented. The space-occupying effects of leukemic cells during leukemic expansion is investigated. The analyses and simulations of the model suggest that acute leukemia is a state in which positions inhabited by colonies of normal cells are invaded by emerging colonies of abnormal cells. Normal cells are then driven to a state of extinction as leukemic cells evolve toward high and dominant steady state levels.
