幽门螺杆菌感染中的抗Lewis X抗体和Lewis X-抗Lewis X免疫复合物

Anti-Lewis X antibody and Lewis X-anti-Lewis X immune complexes in Helicobacter pylori infection.

作者信息

Chmiela M, Wadstrom T, Folkesson H, Płaneta Małecka I, Czkwianianc E, Rechciński T, Rudnicka W

机构信息

Department of Infectious Biology, Institute for Microbiology and Immunology, University of Lodz, Poland.

出版信息

Immunol Lett. 1998 Apr;61(2-3):119-25. doi: 10.1016/s0165-2478(98)00004-2.

DOI:10.1016/s0165-2478(98)00004-2

PMID:9657264

Abstract

A molecular similarity of Lewis antigens expressed by Helicobacter pylori bacteria and those present in human gastric mucosa has been recognised as a cause of autoimmunity involved in the pathogenesis of chronic type B gastritis and gastric and duodenal ulcers. In this study, the expression of Lewis X determinants was found on 56% of H. pylori strains isolated from patients with chronic gastritis/gastroduodenitis. Anti-Lewis X IgG as well as Lewis X-anti-Lewis X IgG complexes were detected in the sera from patients and even more frequently in the sera from healthy blood donors producing antibodies against surface antigens of H. pylori. It suggested that the initial H. pylori-induced lesions were independent of anti-Lewis X antibody production. When H. pylori bacteria expressing Lewis X antigen were treated with anti-Lewis X monoclonal antibody (mAb) of IgM isotype, they were more susceptible to ingestion by polymorphonuclear leukocytes (PMN) than untreated bacteria. This fact may lead us to believe that anti-Lewis X antibody limits the growth of H. pylori on gastric mucosa.

摘要

幽门螺杆菌表达的Lewis抗原与人类胃黏膜中存在的Lewis抗原之间的分子相似性，已被认为是慢性B型胃炎以及胃和十二指肠溃疡发病机制中自身免疫的一个原因。在本研究中，从慢性胃炎/胃十二指肠炎症患者中分离出的幽门螺杆菌菌株，有56%被发现表达Lewis X决定簇。在患者血清中检测到抗Lewis X IgG以及Lewis X-抗Lewis X IgG复合物，在产生抗幽门螺杆菌表面抗原抗体的健康献血者血清中检测到的频率更高。这表明最初由幽门螺杆菌引起的病变与抗Lewis X抗体的产生无关。当用IgM同种型的抗Lewis X单克隆抗体（mAb）处理表达Lewis X抗原的幽门螺杆菌时，它们比未处理的细菌更容易被多形核白细胞（PMN）吞噬。这一事实可能使我们相信，抗Lewis X抗体限制了幽门螺杆菌在胃黏膜上的生长。