Roberts E A, King S M, Fearon M, McGee N
Division of Gastroenterology and Nutrition, Hospital for Sick Children, Toronto, Ontario, Canada.
Acta Gastroenterol Belg. 1998 Apr-Jun;61(2):195-7.
Look-back studies to identify paediatric patients with post-transfusion hepatitis C have been conducted at several tertiary-care hospitals in Canada. A general look-back study was conducted at the Hospital for Sick Children in Toronto for the time period December 1985 to May 1990. All patients transfused at the Hospital for Sick Children during this time period were identified from hospital Blood Bank records. Letters of notification were sent by registered mail to all recipients excluding those known to have died. In the letter anti-HCV testing was recommended. Letters were mailed to 6332 transfusion recipients; 4496 letters were delivered. Of these 146 anti-HCV-positive transfusion recipients (92 pts < 18 yrs old; 54 pts > 18 yrs old) were identified. Sixty-four of these patients were definitely transfused only during this time period. Assuming that all notified patients were tested, the minimum prevalence of new infection in this time period was 1.4%. When possible, identified patients were tested for presence of HCV RNA in the serum by RT-PCR. The proportion of patients anti-HCV positive but HCV RNA negative on one or more occasions was similar in both whole cohort and subset: approximately one-third. These data suggest that chronic hepatitis C may be less likely to develop after transfusion in children than in adults.
加拿大几家三级护理医院开展了回顾性研究，以确定输血后丙型肝炎的儿科患者。1985年12月至1990年5月期间，多伦多病童医院进行了一项全面的回顾性研究。通过医院血库记录确定了这段时间内在病童医院接受输血的所有患者。除已知死亡的患者外，通过挂号信向所有受血者发送了通知信。信中建议进行抗丙型肝炎病毒（HCV）检测。共向6332名输血受血者邮寄了信件；4496封信件送达。其中，确定了146名抗HCV阳性的输血受血者（92名年龄<18岁；54名年龄>18岁）。这些患者中有64名肯定仅在这段时间内接受了输血。假设所有收到通知的患者都进行了检测，那么这段时间内新感染的最低患病率为1.4%。在可能的情况下，对确定的患者通过逆转录聚合酶链反应（RT-PCR）检测血清中HCV RNA的存在情况。在整个队列和子集中，抗HCV阳性但HCV RNA阴性的患者比例相似：约三分之一。这些数据表明，儿童输血后发生慢性丙型肝炎的可能性可能低于成人。
