Therkildsen M H, Andersen L J, Christensen M, Hansen H S, Schiødt T, Dabelsteen E
Department of Pathology, Rigshospitalet, National University Hospital, Copenhagen, Denmark.
Oral Oncol. 1998 Jan;34(1):44-51. doi: 10.1016/s1368-8375(97)00061-4.
The prognosis of salivary gland carcinomas is difficult to assess. Simple mucin-type carbohydrates (T and sialosyl-T antigens, Tn and sialosyl-Tn antigens) have been shown to be of value in predicting prognosis for carcinomas in other locations. We studied the prognostic significance of the expression of these structures in a retrospective study of 133 patients with salivary gland carcinomas, using immunohistochemistry and a panel of well-defined monoclonal antibodies (MAbs) on formalin-fixed paraffin-embedded tissues. Sialosyl-Tn, T and sialosyl-T antigens were not correlated with prognosis. Univariate analyses showed no overall difference in survival or locoregional control between patients with Tn-positive and patients with Tn-negative tumours, but indicated that expression of the Tn antigen was associated with early locoregional recurrences and deaths. Tn was, however, not an independent prognostic factor by multivariate regression analysis.
涎腺癌的预后难以评估。简单粘蛋白型碳水化合物（T和唾液酸化-T抗原、Tn和唾液酸化-Tn抗原）已被证明在预测其他部位癌症的预后方面具有价值。我们在一项对133例涎腺癌患者的回顾性研究中，使用免疫组织化学和一组在福尔马林固定石蜡包埋组织上定义明确的单克隆抗体（MAb），研究了这些结构表达的预后意义。唾液酸化-Tn、T和唾液酸化-T抗原与预后无关。单因素分析显示，Tn阳性肿瘤患者和Tn阴性肿瘤患者在生存率或局部区域控制方面没有总体差异，但表明Tn抗原的表达与早期局部区域复发和死亡相关。然而，通过多变量回归分析，Tn不是一个独立的预后因素。
