DeLint P J, Berendschot T T, van Norren D
Helmholtz Institute, Department of Ophthalmology, Utrecht University, The Netherlands.
Invest Ophthalmol Vis Sci. 1998 Jul;39(8):1519-23.
To compare the measurement of the optical Stiles-Crawford effect (SCE) to the densitometry of cone visual pigments in a clinical setting. Both tests provide information on outer retinal integrity, but the optical SCE can be performed in far less time.
Images acquired with a custom-built scanning laser ophthalmoscope were used to assess visual pigment density and optical SCE. Visual pigment density was regarded as the "gold standard." More than 100 patients with suspected, and some with known, outer retinal pathology were tested. The group included cases of central serous detachment, cone dystrophy, Stargardt's disease, Best's disease, and retinitis pigmentosa.
Parameters of the optical SCE of 25 healthy subjects and 106 patients were taken through a stepwise linear regression to predict density. The correlation between predicted density from the optical SCE and the measured density was 0.82. The sensitivity of the optical SCE to detect decreased density was 96%. When only the foveal reflectance was considered, sensitivity was still 84%
The optical SCE is a sensitive and fast method for detecting cone photoreceptor disturbances.
在临床环境中比较光学斯泰尔斯 - 克劳福德效应（SCE）测量与视锥细胞视觉色素密度测定。这两种测试都能提供关于视网膜外层完整性的信息，但光学SCE的检测时间要短得多。
使用定制的扫描激光检眼镜获取的图像来评估视觉色素密度和光学SCE。视觉色素密度被视为“金标准”。对100多名疑似患有视网膜外层病变以及部分已知患有视网膜外层病变的患者进行了测试。该组包括中心性浆液性脱离、视锥细胞营养不良、斯塔加特病、贝斯特病和色素性视网膜炎等病例。
通过逐步线性回归获取了25名健康受试者和106名患者的光学SCE参数，以预测密度。光学SCE预测密度与测量密度之间的相关性为0.82。光学SCE检测密度降低的敏感性为96%。仅考虑中央凹反射率时，敏感性仍为84%。
光学SCE是检测视锥细胞光感受器功能障碍的一种敏感且快速的方法。
