Freeman T W, Cardwell D, Karson C N, Komoroski R A
Department of Psychiatry, University of Arkansas for Medical Sciences, and McClellan VA Medical Center, Little Rock 72205, USA.
Magn Reson Med. 1998 Jul;40(1):66-71. doi: 10.1002/mrm.1910400110.
Recent findings using volumetric MRI techniques have revealed that patients with combat-related and noncombat-related posttraumatic stress disorder (PTSD) have reductions in right hippocampal volume. Twenty-one veterans with PTSD and eight age-matched control veterans were studied using proton magnetic resonance spectroscopy to test the hypothesis that the N-acetyl-L-aspartic acid/creatine (NAA/Cr) ratio would be decreased in the right medial temporal lobe structures of patients with PTSD compared to controls. Patients with PTSD displayed significantly lower NAA/Cr ratio for the right medial temporal lobe relative to the left (P < or = 0.011). Patients with PTSD also had lower NAA/Cr in right medial temporal lobe (P < or = 0.013) and lower choline/Cr in left medial temporal lobe (P < or = 0.030) compared to control subjects. Because NAA is regarded as an indicator of neuronal density, this finding suggests that the neuronal density of right-sided medial temporal structures in patients with combat-related PTSD may be decreased.
近期使用容积磁共振成像技术的研究结果显示，患有与战斗相关和非战斗相关创伤后应激障碍（PTSD）的患者右侧海马体体积减小。对21名患有创伤后应激障碍的退伍军人和8名年龄匹配的对照退伍军人进行了质子磁共振波谱研究，以检验以下假设：与对照组相比，创伤后应激障碍患者右侧颞叶内侧结构中的N-乙酰-L-天冬氨酸/肌酸（NAA/Cr）比值会降低。与左侧相比，患有创伤后应激障碍的患者右侧颞叶内侧的NAA/Cr比值显著更低（P≤0.011）。与对照受试者相比，患有创伤后应激障碍的患者右侧颞叶内侧的NAA/Cr也更低（P≤0.013），左侧颞叶内侧的胆碱/肌酸更低（P≤0.030）。由于NAA被视为神经元密度的指标，这一发现表明，患有与战斗相关创伤后应激障碍的患者右侧颞叶内侧结构的神经元密度可能降低。
