• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

来自伞房花弗吉尼亚木(蔷薇科)的肿瘤抑制因子。

Tumor inhibitory agents from Vauquelinia corymbosa (Rosaceae).

作者信息

Trumbull E R, Bianchi E, Eckert D J, Wiedhopf R M, Cole J R

出版信息

J Pharm Sci. 1976 Sep;65(9):1407-8. doi: 10.1002/jps.2600650938.

DOI:10.1002/jps.2600650938
PMID:966165
Abstract

The chloroform extract of Vauquelinia corymbosa Correa has shown activity against the P-388 lymphocytic leukemia test system. The constituents responsible for this activity were identified as uvaol, ursolic acid, and betulinic acid. Their identity was proven by melting point; mixed melting point; elemental analysis; IR, PMR, and mass spectra; and preparation of derivatives.

摘要

伞房花瓦奎木(Vauquelinia corymbosa Correa)的氯仿提取物已显示出对P - 388淋巴细胞白血病测试系统有活性。负责此活性的成分被鉴定为羽扇豆醇、熊果酸和桦木酸。它们的身份通过熔点、混合熔点、元素分析、红外光谱、核磁共振氢谱和质谱以及衍生物的制备得以证明。

相似文献

1
Tumor inhibitory agents from Vauquelinia corymbosa (Rosaceae).来自伞房花弗吉尼亚木(蔷薇科)的肿瘤抑制因子。
J Pharm Sci. 1976 Sep;65(9):1407-8. doi: 10.1002/jps.2600650938.
2
α-Glucosidase Inhibitors from Vauquelinia corymbosa.来自伞房花瓦奎木的α-葡萄糖苷酶抑制剂
Molecules. 2015 Aug 21;20(8):15330-42. doi: 10.3390/molecules200815330.
3
Cytotoxic and tumor inhibitory agent from Polygala macradenia Gray (Polygalaceae): 4'-demethyldeoxypodophyllotoxin.来自大远志(远志科)的细胞毒性和肿瘤抑制剂:4'-去甲基脱氧鬼臼毒素。
J Pharm Sci. 1977 Apr;66(4):586-7. doi: 10.1002/jps.2600660433.
4
Antitumor agents from Jatropha macrorhiza (Euphorbiaceae) III: acetylaleuritolic acid.
J Pharm Sci. 1977 Sep;66(9):1348-9. doi: 10.1002/jps.2600660941.
5
New 3-O-acyl betulinic acids from Strychnos vanprukii Craib.来自马钱子属植物Strychnos vanprukii Craib的新型3-O-酰基桦木酸
J Nat Prod. 2004 Jun;67(6):994-8. doi: 10.1021/np030469i.
6
Potential anticancer agents. IV. Constituents of Jacaranda caucana Pittier (Bignoniaceae).
Lloydia. 1977 Mar-Apr;40(2):157-68.
7
Cytotoxic triterpenes from stem bark of Physocarpus intermedius.中间锦鸡儿茎皮中的细胞毒性三萜类化合物。
Planta Med. 2000 Jun;66(5):485-6. doi: 10.1055/s-2000-8585.
8
[Advances in the study of structural modifications and biological activities of betulinic acids].桦木酸的结构修饰及其生物活性研究进展
Yao Xue Xue Bao. 2010 Nov;45(11):1339-45.
9
Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants.从秘鲁亚马逊地区的靶向药用植物中分离细胞毒性代谢物。
J Nat Prod. 2008 Jan;71(1):102-5. doi: 10.1021/np070560c. Epub 2007 Dec 29.
10
Cytotoxic agents from Bursera klugii (Burseraceae) I: isolation of sapelins A and B.
J Pharm Sci. 1977 Jun;66(6):889-90. doi: 10.1002/jps.2600660645.

引用本文的文献

1
Advancements in Betulinic Acid-Loaded Nanoformulations for Enhanced Anti-Tumor Therapy.用于增强抗肿瘤治疗的负载桦木酸纳米制剂的进展
Int J Nanomedicine. 2024 Dec 29;19:14075-14103. doi: 10.2147/IJN.S493489. eCollection 2024.
2
Construction, structural modification, and bioactivity evaluation of pentacyclic triterpenoid privileged scaffolds in active natural products.活性天然产物中五环三萜类优势骨架的构建、结构修饰及生物活性评价
RSC Adv. 2024 Dec 13;14(53):39436-39461. doi: 10.1039/d4ra07602h. eCollection 2024 Dec 10.
3
Effect of Triterpenoids Betulin and Betulinic Acid on Pulmonary Surfactant Membranes.
三萜类化合物桦木醇和桦木酸对肺表面活性物质膜的影响。
J Membr Biol. 2025 Feb;258(1):47-61. doi: 10.1007/s00232-024-00329-w. Epub 2024 Dec 7.
4
The Influence of Betulin Derivatives EB5 and ECH147 on the Expression of Selected TGFβ Superfamily Genes, , and , in Renal Proximal Tubule Epithelial Cells.桦木醇衍生物EB5和ECH147对肾近端小管上皮细胞中选定的TGFβ超家族基因、 、 和 表达的影响。
Curr Issues Mol Biol. 2023 Dec 12;45(12):9961-9975. doi: 10.3390/cimb45120622.
5
Betulinic Acid Protects from Ischemia-Reperfusion Injury in the Mouse Retina.桦木酸可保护小鼠视网膜免受缺血再灌注损伤。
Cells. 2021 Sep 16;10(9):2440. doi: 10.3390/cells10092440.
6
Garland, Flower, and Petals via a Hierarchical Self-Assembly of Ursane-Type Triterpenoid Uvaol.通过乌苏烷型三萜类化合物乌索酸的分级自组装形成花环、花朵和花瓣。
ACS Omega. 2021 Jul 27;6(31):20560-20568. doi: 10.1021/acsomega.1c02630. eCollection 2021 Aug 10.
7
Biocatalysis in the Chemistry of Lupane Triterpenoids.生物催化在羽扇烷三萜类化合物化学中的应用。
Molecules. 2021 Apr 14;26(8):2271. doi: 10.3390/molecules26082271.
8
Chemical Strategies towards the Synthesis of Betulinic Acid and Its More Potent Antiprotozoal Analogues.化学策略在白桦脂酸及其更有效的抗寄生虫类似物合成中的应用。
Molecules. 2021 Feb 18;26(4):1081. doi: 10.3390/molecules26041081.
9
Recent Achievements in Medicinal and Supramolecular Chemistry of Betulinic Acid and Its Derivatives .桦木酸及其衍生物的药用和超分子化学的最新研究进展。
Molecules. 2019 Sep 30;24(19):3546. doi: 10.3390/molecules24193546.
10
α-Glucosidase Inhibitors from Vauquelinia corymbosa.来自伞房花瓦奎木的α-葡萄糖苷酶抑制剂
Molecules. 2015 Aug 21;20(8):15330-42. doi: 10.3390/molecules200815330.