Grooming in Lurcher mutant mice.

Lurcher mutant mice, characterized by degeneration of cerebellar Purkinje cells and granule cells, were compared to normal littermate controls for different facets of grooming and nongrooming behaviors after a brief period of water immersion. By comparison to normal controls, the number and the duration of several grooming components were decreased in Lurcher mutant mice, namely, licking the forelimb, the abdomen, the back, and the hindlimb. By contrast, the number and duration of body-shaking episodes were not reduced. Lurcher mutants had fewer grooming elements for bouts with at least five elements. However, the serial organization of grooming, as determined by the order of appearance of grooming elements, was maintained in Lurcher mutants. These results indicate that the cerebellar cortex is involved in the appearance of various grooming elements but not in the organization of the cephalocaudal sequence.