Gendenshteĭn E I, Volkova N D, Oleĭnikova E A, Novikova L V
Farmakol Toksikol. 1977 Mar-Apr;40(2):174-7.
Tests conducted with 125 cats demonstrated that occlusion of the coronary artery causes a higher sensitivity to the bathmotropic action of strophanthin, but does not have any effect on the magnitude of its lethal dose. The efficaciousness of potassium orotate and also of Na2EDTA in combinations with anapriline and isadrine, as regulators of the sensitivity to the toxic effect of strophanthin, was investigated. Immunization of cats with a homocardiac antigen was found to produce biphasic changes in the sensitivity to the toxic effect of strophanthin associated with the duration of antigenic stimulation.
对125只猫进行的试验表明，冠状动脉闭塞会导致对毒毛旋花子苷变力作用的敏感性更高，但对其致死剂量的大小没有任何影响。研究了乳清酸钾以及Na2EDTA与心得安和异丙肾上腺素联合使用作为调节对毒毛旋花子苷毒性作用敏感性的有效性。发现用同种心脏抗原对猫进行免疫会导致与抗原刺激持续时间相关的对毒毛旋花子苷毒性作用敏感性的双相变化。
