Torkhovskaia T I, Lobova N M, Levitova E N
Kardiologiia. 1976 Feb;16(2):46-9.
The composition of phospholipids of plasma lipoproteins was studied in normal individuals and in patients with coronary atherosclerosis with type IIb and IV hyperlipoproteidemia using two-dimentional thin-layer chromatography. It was demonstrated that in normals the fractions of lipoproteins of a very low, low and high density have an even distribution of most of the phospholipid components, lecithin and sphyngomyelin being the prevailing phospholipids in all fractions of lipoproteins. In type IIb and IV hyperlipoproteidemia, lipoprotein fractions of very low density have a relatively elevated content of lecithin and those of high density have an elevated content of lecithin and lysolecithin and a decreased level of sphyngomyelin. The obtained data are discussed in terms of the possible effect of the chemical composition of phospholipids on the properties of lipoproteins in atherosclerosis.
采用二维薄层色谱法，对正常个体以及患有IIb型和IV型高脂蛋白血症的冠状动脉粥样硬化患者血浆脂蛋白中的磷脂成分进行了研究。结果表明，在正常情况下，极低密度、低密度和高密度脂蛋白组分中大多数磷脂成分分布均匀，卵磷脂和鞘磷脂是所有脂蛋白组分中的主要磷脂。在IIb型和IV型高脂蛋白血症中，极低密度脂蛋白组分中卵磷脂含量相对升高，而高密度脂蛋白组分中卵磷脂和溶血卵磷脂含量升高，鞘磷脂水平降低。从磷脂化学成分对动脉粥样硬化中脂蛋白性质的可能影响方面，对所得数据进行了讨论。
