Gilchrist T, Glasby M A, Healy D M, Kelly G, Lenihan D V, McDowall K L, Miller I A, Myles L M
Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Scotland, UK.
Br J Plast Surg. 1998 Apr;51(3):231-7. doi: 10.1054/bjps.1997.0243.
Biodegradeable "controlled release" inorganic polymer glass tubes can be manufactured to fit the dimensions of any nerve and their rate of solubility can be adjusted to encompass the time taken for nerve regeneration. They have been used in a number of biological applications. The facial nerve was repaired in a group of five sheep by entubulation with biodegradeable glass tubes. The sheep were assessed 10 months after repair and compared with a similar sized group of normal sheep. It was found that while there was a reduction in the peak velocity of conduction in the repaired nerves and in the range of conduction velocities, the minimum conduction velocity was within normal limits. There was a diminution in all of the measured variables of nerve morphometry but in no case did this reach statistical significance. These findings are consistent with the view that regeneration of the nerves had taken place to a degree at least as effective as that seen in nerves of a similar size repaired by conventional means.
可生物降解的“控释”无机聚合物玻璃管能够制造得适合任何神经的尺寸，并且其溶解速率可以调节，以涵盖神经再生所需的时间。它们已被用于多种生物学应用中。通过用可生物降解的玻璃管进行套管法修复了一组五只绵羊的面神经。在修复后10个月对绵羊进行评估，并与一组大小相似的正常绵羊进行比较。结果发现，虽然修复神经的传导峰值速度和传导速度范围有所降低，但最小传导速度仍在正常范围内。神经形态测量的所有测量变量均有减少，但在任何情况下均未达到统计学意义。这些发现与以下观点一致，即神经至少在一定程度上发生了再生，其效果与通过传统方法修复的相似大小神经中所见的效果相同。
