Washio Ayako, Morotomi Takahiko, Yoshii Shinji, Kitamura Chiaki
Division of Endodontics and Restorative Dentistry, Department of Oral Functions, Kyushu Dental University, Kitakyushu 803-8580, Japan.
Materials (Basel). 2019 Nov 29;12(23):3967. doi: 10.3390/ma12233967.
Endodontic treatment for a tooth with damaged dental pulp aims to both prevent and cure apical periodontitis. If the tooth is re-infected as a result of a poorly obturated root canal, periapical periodontitis may set-in due to invading bacteria. To both avoid any re-infection and improve the success rate of endodontic retreatment, a treated root canal should be three-dimensionally obturated with a biocompatible filling material. Recently, bioactive glass, one of the bioceramics, is focused on the research area of biocompatible biomaterials for endodontics. Root canal sealers derived from bioactive glass-based have been developed and applied in clinical endodontic treatments. However, at present, there is little evidence about the patient outcomes, sealing mechanism, sealing ability, and removability of the sealers. Herein, we have developed a bioactive glass-based root canal sealer and provided evidence concerning its physicochemical properties, biocompatibility, sealing ability, and removability. We also review the classification of bioceramics and characteristics of bioactive glass. Additionally, we describe the application of bioactive glass to facilitate the development of a new root canal sealer. Furthermore, this review shows the potential application of bioactive glass-based cement as a root canal filling material in the absence of semisolid core material.
对牙髓受损的牙齿进行根管治疗旨在预防和治愈根尖周炎。如果根管充填不佳导致牙齿再次感染，侵入的细菌可能会引发根尖周炎。为避免再次感染并提高根管再治疗的成功率，应使用生物相容性填充材料对治疗后的根管进行三维充填。近年来，生物活性玻璃作为生物陶瓷的一种，成为牙髓病生物相容性生物材料研究领域的焦点。基于生物活性玻璃的根管封闭剂已被研发并应用于临床根管治疗。然而，目前关于这些封闭剂的患者治疗效果、封闭机制、封闭能力及可去除性的证据较少。在此，我们研发了一种基于生物活性玻璃的根管封闭剂，并提供了有关其物理化学性质、生物相容性、封闭能力及可去除性的证据。我们还综述了生物陶瓷的分类及生物活性玻璃的特性。此外，我们描述了生物活性玻璃在新型根管封闭剂研发中的应用。此外，本综述展示了在没有半固体核心材料的情况下，基于生物活性玻璃的水门汀作为根管充填材料的潜在应用。
