Valmaggia C, Bischoff P, Ries G, Seelentag W, Niederberger H, Speiser P
Department of Ophthalmology, Kantonsspital St. Gallen, Switzerland.
Doc Ophthalmol. 1997;93(4):317-26. doi: 10.1007/BF02569069.
The aim of our pilot study was to test the effect of low dose radiation on classic and occult subfoveal choroidal neovascularization (CNV) in age-related macular degeneration (AMD). The posterior pole of the afflicted eye of 12 patients was irradiated with 5 Gray (Gy), and that of 34 patients with 8 Gy. The radiotherapy was done by a linear accelerator (6 MV X-rays) during 4 consecutive days with daily doses of 1.25 Gy and 2 Gy respectively. At the time of treatment, and 6 weeks, 6 months and 1 year after, a simultaneous fluorescein and ICG angiography of both eyes were carried out, and the distance visual acuity was measured. In none of the cases were we able to note a reduction in the subfoveal membrane's size. With regards to the visual acuity, the evolution was slightly better than the spontaneous courses described in existing literature. Further prospective randomized studies with higher dose radiation are necessary in order to determine the significance of radiotherapy in the treatment of this pathology.
我们的初步研究目的是测试低剂量辐射对年龄相关性黄斑变性（AMD）中典型和隐匿性黄斑下脉络膜新生血管（CNV）的影响。12例患者患眼的后极接受5格雷（Gy）的辐射，34例患者接受8 Gy的辐射。放疗通过直线加速器（6兆伏X射线）进行，连续4天，每日剂量分别为1.25 Gy和2 Gy。在治疗时以及治疗后6周、6个月和1年，对双眼进行同步荧光素和吲哚菁绿血管造影，并测量远视力。在所有病例中，我们均未观察到黄斑下膜大小减小。关于视力，其进展略优于现有文献中描述的自然病程。为了确定放疗在这种疾病治疗中的意义，有必要进行进一步的高剂量辐射前瞻性随机研究。
