Pusterla N, Weber R, Wolfensberger C, Schär G, Zbinden R, Fierz W, Madigan J E, Dumler J S, Lutz H
Department of Veterinary Internal Medicine, University of Zurich, Switzerland.
Eur J Clin Microbiol Infect Dis. 1998 Mar;17(3):207-9. doi: 10.1007/BF01691120.
To investigate whether human granulocytic ehrlichiosis (HGE) is prevalent in Switzerland, 1515 human serum samples from individuals with different risks for tick exposure were tested for antibodies to Ehrlichia phagocytophila, a surrogate marker of the agent of HGE. The distribution of titres showed marked differences between sera of individuals with no or low risk for tick exposure and those with a high risk. The results of serological testing provided evidence of HGE in Switzerland as well as evidence of two types of coinfections: those with the agent of HGE and Borrelia burgdorferi, and those with the agent of HGE and the central European tickborne encephalitis virus.
为调查人类粒细胞埃立克体病（HGE）在瑞士是否流行，对1515份来自不同蜱虫暴露风险个体的人血清样本进行检测，以寻找嗜吞噬细胞无形体抗体，嗜吞噬细胞无形体是HGE病原体的替代标志物。抗体滴度分布显示，蜱虫暴露风险低或无风险个体的血清与高风险个体的血清之间存在显著差异。血清学检测结果为瑞士存在HGE提供了证据，同时也证明了两种混合感染情况：一是感染HGE病原体与伯氏疏螺旋体；二是感染HGE病原体与中欧蜱传脑炎病毒。
