人体对短链和中链C2 - C10脂肪酸的直肠吸收。
Human rectal absorption of short- and medium-chain C2-C10 fatty acids.
作者信息
Jørgensen J, Holtug K, Jeppesen P B, Mortensen P B
机构信息
Dept. of Medicine CA 2121, Copenhagen University Hospital, Rigshospitalet, Denmark.
出版信息
Scand J Gastroenterol. 1998 Jun;33(6):590-4. doi: 10.1080/00365529850171846.
BACKGROUND
Current knowledge on the colonorectal absorption of medium-chain fatty acids is limited. The purpose of the present study was to evaluate and compare the human rectal absorption of short- and medium-chain C2-C10 fatty acids in healthy volunteers.
METHODS
Dialysis bags containing 20 mmol x l(-1) of the fatty acids acetate, butyrate, hexanoate, octanoate, or decanoate in a phosphate-buffered (pH neutral) isoosmotic electrolyte solution were placed in the rectum for 30 min in 14 healthy volunteers. Absorption rates were calculated for all fatty acids, sodium, potassium, and water.
RESULTS
Absorption rates of the fatty acids acetate, butyrate, hexanoate, octanoate or decanoate were the same (1.9 +/- 0.1 = 2.5 +/- 0.2 = 1.7 +/- 0.2 = 1.9 +/- 0.2 = 2.2 +/- 0.1 micromol x cm(-2) x h(-1) (mean +/- standard error of the mean), respectively; P = 0.24).
CONCLUSIONS
Medium-chain fatty acids were absorbed in the human rectum at a rate similar to that for short-chain fatty acids. If results can be applied to the human colon, colonic absorption of medium-chain fatty acids could possibly become an important secondary site of absorption in abnormal intestinal conditions such as massive small-intestinal resection or malabsorption syndromes.
背景
目前关于中链脂肪酸在结肠直肠吸收方面的知识有限。本研究的目的是评估和比较健康志愿者中短链和中链C2 - C10脂肪酸的直肠吸收情况。
方法
将含有20 mmol·L⁻¹乙酸、丁酸、己酸、辛酸或癸酸的透析袋置于磷酸盐缓冲（pH中性）等渗电解质溶液中，放入14名健康志愿者的直肠内30分钟。计算所有脂肪酸、钠、钾和水的吸收率。
结果
乙酸、丁酸、己酸、辛酸或癸酸的吸收率相同（分别为1.9±0.1 = 2.5±0.2 = 1.7±0.2 = 1.9±0.2 = 2.2±0.1 μmol·cm⁻²·h⁻¹（平均值±平均标准误差）；P = 0.24）。
结论
中链脂肪酸在人体直肠中的吸收速率与短链脂肪酸相似。如果研究结果可应用于人体结肠，那么在诸如大量小肠切除或吸收不良综合征等异常肠道状况下，中链脂肪酸的结肠吸收可能会成为一个重要的次要吸收部位。
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