库鲁病与新型克雅氏病的比较神经病理学：病原体毒株比宿主基因型更具主导性的证据
Comparative neuropathology of Kuru with the new variant of Creutzfeldt-Jakob disease: evidence for strain of agent predominating over genotype of host.
作者信息
McLean C A, Ironside J W, Alpers M P, Brown P W, Cervenakova L, Anderson R M, Masters C L
机构信息
Department of Pathology, The University of Melbourne, Victoria, Australia.
出版信息
Brain Pathol. 1998 Jul;8(3):429-37. doi: 10.1111/j.1750-3639.1998.tb00165.x.
Abstract
The three major influences on the phenotype of the transmissible spongiform encephalopathies are believed to be strain of agent, route of infection and host genotype. We have compared the pathologic profiles and genotypes of the new variant of Creutzfeldt-Jakob disease (vCJD) and kuru. The comparison reveals that there are distinct lesional differences particularly in the prion protein (PrP) load and distribution as seen by immunohistochemistry. The clinico-pathologic phenotypes and the genotypes of these two diseases are sufficiently different to suggest that the strain of agent may play a greater role than any presumptive common route of peripherally acquired infection.
摘要
一般认为，对传染性海绵状脑病表型产生主要影响的三个因素是病原体毒株、感染途径和宿主基因型。我们比较了新型克雅氏病（vCJD）和库鲁病的病理特征及基因型。比较结果显示，二者在病变方面存在明显差异，尤其是通过免疫组化观察到的朊病毒蛋白（PrP）负荷及分布情况。这两种疾病的临床病理表型和基因型差异显著，表明病原体毒株可能比任何推测的外周感染常见途径发挥着更大的作用。
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