Velayos J L, Oliva M, Alfageme F
Faculty of Medicine, Autonomous University of Madrid, Spain.
Brain Pathol. 1998 Jul;8(3):549-52. doi: 10.1111/j.1750-3639.1998.tb00177.x.
Afferent projections to the mediodorsal and anterior thalamic nuclei in the cat were studied by means of stereotaxic injection of neuronal tracers (horseradish peroxidase and fluorochromes). Acetylcholinesterase reaction was studied, as well as horseradish peroxidase and NADPH-diaphorase colocation in neuronal bodies which send and receive projections to and from the mediodorsal thalamic nucleus. Based on the connectivity and histochemistry findings, the possibility that prion agents responsible for fatal familial insomnia spread from the mediodorsal and anterior thalamic nuclei through a retrograde pathway is discussed. The possible pathophysiological implication of nitrergic systems in fatal familial insomnia is also considered.
通过立体定位注射神经元示踪剂（辣根过氧化物酶和荧光染料），研究了猫中向丘脑背内侧核和前丘脑核的传入投射。研究了乙酰胆碱酯酶反应，以及在向丘脑背内侧核发送和接收投射的神经元体中辣根过氧化物酶和NADPH - 黄递酶的共定位情况。基于连接性和组织化学研究结果，讨论了导致致死性家族性失眠的朊病毒因子通过逆行途径从丘脑背内侧核和前丘脑核传播的可能性。还考虑了氮能系统在致死性家族性失眠中可能的病理生理意义。
