Kassamali H, Anaissie E, Ro J, Rolston K, Kantarjian H, Fainstein V, Bodey G P
Department of Internal Medicine, University of Texas M. D. Anderson Hospital and Tumor Institute, Houston 77030.
J Clin Microbiol. 1987 Sep;25(9):1782-3. doi: 10.1128/jcm.25.9.1782-1783.1987.
The pathogenicity of the fungus Geotrichum candidum in humans has not been clearly defined. A patient with acute leukemia who developed a fatal disseminated G. candidum infection while neutropenic is described. At autopsy examination, this patient was misdiagnosed on the basis of histopathology as having disseminated candidiasis until G. candidum was isolated from postmortem culture specimens. The emergence of this organism as an occasional pathogen in leukemic patients is of interest and illustrates the importance of obtaining fungal cultures. There is a need for more effective drugs for antifungal prophylaxis and therapy.
白地霉在人类中的致病性尚未明确界定。本文描述了一名急性白血病患者，在中性粒细胞减少期间发生了致命的播散性白地霉感染。尸检时，根据组织病理学，该患者被误诊为播散性念珠菌病，直到从尸检培养标本中分离出白地霉。这种微生物作为白血病患者偶尔出现的病原体，值得关注，并说明了进行真菌培养的重要性。需要有更有效的药物用于抗真菌预防和治疗。
