Syntheses and cardiovascular effects of some S-substituted 4-chloro-2-mercapto-5-methyl-N-(4-alkyl-4H-1,2,4-triazol-3-yl) benzenesulfonamides.

Syntheses of N-(2-dialkylaminoethyl)-(5-chloro-4-methyl-2-[(4-butyl or isobutyl -4H-1,2,4-triazol-3-yl)aminosulfonyl]phenylthio) alkanecarboxyamides [VII-X] and hydrochlorides [VIIa-Xa, XI-XIII] are described. Results of preliminary pharmacological examination such as acute toxicity and influence on the circulatory system of compounds [VIIa, IXa, Xa, XIII, XIV] are presented. The antiarrhythmic effect of the most active [IXa] was comparable to the reference procainamide.