Sławiński J
Department of Chemical Drug Technology, Medical University of Gdańsk, Poland.
Acta Pol Pharm. 1998 Mar-Apr;55(2):129-35.
Syntheses of N-(2-dialkylaminoethyl)-(5-chloro-4-methyl-2-[(4-butyl or isobutyl -4H-1,2,4-triazol-3-yl)aminosulfonyl]phenylthio) alkanecarboxyamides [VII-X] and hydrochlorides [VIIa-Xa, XI-XIII] are described. Results of preliminary pharmacological examination such as acute toxicity and influence on the circulatory system of compounds [VIIa, IXa, Xa, XIII, XIV] are presented. The antiarrhythmic effect of the most active [IXa] was comparable to the reference procainamide.
描述了N-(2-二烷基氨基乙基)-(5-氯-4-甲基-2-[(4-丁基或异丁基-4H-1,2,4-三唑-3-基)氨基磺酰基]苯硫基)链烷羧酰胺[VII-X]及其盐酸盐[VIIa-Xa，XI-XIII]的合成。给出了初步药理检查结果，如化合物[VIIa、IXa、Xa、XIII、XIV]的急性毒性及对循环系统的影响。活性最强的化合物[IXa]的抗心律失常作用与对照药普鲁卡因胺相当。
