2-巯基苯磺酰胺的衍生物。十七。1- [4-R-5-氰基-2-二烷基氨基烷基硫代）苯磺酰基]-2-咪唑烷二酮盐酸盐的合成及某些药理性质。
Derivatives of 2-mercaptobenzenesulphonamide. XVII. Synthesis and some pharmacological properties of 1-[4-R-5-cyano-2-dialkylaminoalkylthio)benzenesulphonyl]-2-imidiazolidi none hydrochlorides.
作者信息
Pomarnacka E, Brzozowski Z, Gajewski F, Filczewski M, Oledzka K, Kosmala M, Sliwoska M
机构信息
Department of Drug Technology, School of Medicine, Gdańsk, Poland.
出版信息
Acta Pol Pharm. 1994;51(4-5):393-401.
PMID:7701953
Abstract
Syntheses of 1-[4-R-5-cyano-2-(dialkylaminoalkylthio)-benzenesulphonyl]- 2-imidiazolidinones [IIIa-h,IVa-m] and their hydrochlorides [Va-h, VIa-m] are described herein. The results of preliminary pharmacological examinations, such as acute toxicity and influence on the circulatory system are presented. Some structure-activity relationship are also discussed.
摘要
本文描述了1-[4-R-5-氰基-2-(二烷基氨基烷基硫基)-苯磺酰基]-2-咪唑烷酮[IIIa-h，IVa-m]及其盐酸盐[Va-h，VIa-m]的合成。给出了初步药理学检查的结果，如急性毒性和对循环系统的影响。还讨论了一些构效关系。
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