Synthesis, structural characterization and antimicrobial studies of 2,4-pentanedione derivatives. Part I.

The title compounds have been synthesized in good yields by the interaction of 2,3,4-pentanetrione-3-oxime with ethanedithioamide in 1:1, 1:2, and 2:2 mole proportions. The structures of these compounds have been elucidated from its physico-chemical and spectral data and by correlation with well-known products. Preliminary screening of these compounds for biological activity against several microorganisms has indicated that they are selective growth inhibitors of Mycobacterium tuberculosis in particular.