因溃疡性结肠炎行结肠切除术患者口服霍乱疫苗后回肠造口液和血清中的免疫反应。
Immune responses in ileostomy fluid and serum after oral cholera vaccination of patients colectomized because of ulcerative colitis.
作者信息
Kilhamn J, Brevinge H, Svennerholm A M, Jertborn M
机构信息
Departments of Medical Microbiology and Immunology, Göteborg University, Göteborg, Sweden.
出版信息
Infect Immun. 1998 Aug;66(8):3995-9. doi: 10.1128/IAI.66.8.3995-3999.1998.
Abstract
The capacity of an oral inactivated B-subunit-whole-cell cholera vaccine to induce immune responses in patients colectomized due to ulcerative colitis was studied. Two doses of vaccine induced significant mucosal immunoglobulin A (IgA) antibody responses in ileostomy fluid against cholera toxin in 14 of 15 (93%) patients and against whole vibrios in 9 of 15 (60%) cases. The serological responses were lower (but not significantly) than those observed in healthy Swedish volunteers. Increased IgA antitoxin levels were found in ileostomy fluid as late as 2 years after vaccination.
摘要
研究了口服灭活B亚单位全细胞霍乱疫苗在因溃疡性结肠炎接受结肠切除术的患者中诱导免疫反应的能力。两剂疫苗在15名患者中的14名（93%）的回肠造口液中诱导了针对霍乱毒素的显著黏膜免疫球蛋白A（IgA）抗体反应，在15名患者中的9名（60%）的回肠造口液中诱导了针对全弧菌的显著黏膜免疫球蛋白A（IgA）抗体反应。血清学反应低于（但无显著差异）在健康瑞典志愿者中观察到的反应。在接种疫苗后长达2年的回肠造口液中发现IgA抗毒素水平升高。
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