结核分枝杆菌H37Rv对色氨酸的摄取：利福平和乙胺丁醇的影响。
Tryptophan uptake by Mycobacterium tuberculosis H37Rv: effect of rifampin and ethambutol.
作者信息
Sundaram K S, Venkitasubramanian T A
出版信息
Antimicrob Agents Chemother. 1978 May;13(5):726-30. doi: 10.1128/AAC.13.5.726.
Abstract
Uptake of radioactive tryptophan by Mycobacterium tuberculosis H(37)Rv grown in vitro and in vivo was investigated. K(m) values indicated low affinity, and sodium azide inhibited uptake. Rifampin at the minimal inhibitory concentration had no effect, whereas ethambutol inhibited uptake only in the bacilli grown under in vitro conditions. The significance of these results is discussed.
摘要
对在体外和体内生长的结核分枝杆菌H(37)Rv摄取放射性色氨酸的情况进行了研究。米氏常数（K(m)）值表明亲和力较低，并且叠氮化钠抑制摄取。最低抑菌浓度的利福平没有影响，而乙胺丁醇仅在体外培养条件下生长的杆菌中抑制摄取。讨论了这些结果的意义。
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