Van Vugt J M, Tinnemans B W, Van Zalen-Sprock R M
Department of Obstetrics and Gynecology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands.
Ultrasound Obstet Gynecol. 1998 Jun;11(6):407-9. doi: 10.1046/j.1469-0705.1998.11060407.x.
The aim of this study was to evaluate pregnancy outcome and early childhood of chromosomally normal fetuses with increased nuchal translucency at 10-14 weeks' gestation. A total of 63 chromosomally normal fetuses with a first-trimester nuchal translucency thickness of 3 mm or more were evaluated. In ongoing pregnancies, follow-up scans were performed to detect or exclude additional structural anomalies in the fetus. Follow-up of the live-born children was by questionnaires sent to parents or reviews of medical records. In 11 fetuses, additional structural anomalies were diagnosed at follow-up scans; in this group there were five terminations of pregnancy, two intrauterine deaths, two neonatal deaths and two survivors. In addition, there were two unexplained intrauterine deaths. The remaining 50 pregnancies resulted in live births and the parents were sent questionnaires on the follow-up of their children. Responses were received on 34 children at 7-75 months of age. Twenty-nine children are healthy and five showed various minor health problems not related to the presence of increased nuchal translucency. These findings suggest that chromosomally normal fetuses with first-trimester increased nuchal translucency and normal follow-up scans have a good prognosis for a normal early childhood.
本研究的目的是评估孕10 - 14周时颈部透明带增厚但染色体正常的胎儿的妊娠结局及幼儿期情况。共评估了63例孕早期颈部透明带厚度为3毫米或以上的染色体正常胎儿。对于持续妊娠的情况，进行随访扫描以检测或排除胎儿的其他结构异常。对活产儿童的随访通过向父母发送问卷或查阅病历进行。在11例胎儿中，随访扫描时诊断出其他结构异常；该组中有5例终止妊娠，2例宫内死亡，2例新生儿死亡，2例存活。此外，还有2例不明原因的宫内死亡。其余50例妊娠分娩出活产儿，并向其父母发送了关于孩子随访情况的问卷。收到了34名7至75个月大儿童的回复。29名儿童健康，5名儿童出现了各种与颈部透明带增厚无关的轻微健康问题。这些发现表明，孕早期颈部透明带增厚且染色体正常、随访扫描正常的胎儿在幼儿期预后良好。
