相似文献
1
The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation.肿瘤抑制因子Smad4/DPC4和转录衔接蛋白CBP/p300是转化生长因子β（TGF-β）诱导的转录激活过程中Smad3的共激活因子。
Genes Dev. 1998 Jul 15;12(14):2153-63. doi: 10.1101/gad.12.14.2153.
2
TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300.转化生长因子-β刺激下Smad蛋白与共激活因子CBP/p300的协同作用。
Genes Dev. 1998 Jul 15;12(14):2114-9. doi: 10.1101/gad.12.14.2114.
3
Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-beta involves functional cooperation with p300/CBP transcriptional coactivators.转化生长因子-β（TGF-β）通过Smad依赖的方式刺激人皮肤成纤维细胞中I型胶原蛋白基因的表达，这一过程涉及与p300/CBP转录共激活因子的功能协同作用。
Oncogene. 2000 Jul 20;19(31):3546-55. doi: 10.1038/sj.onc.1203693.
4
Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein.肿瘤抑制因子Smad4是一种转化生长因子β诱导型DNA结合蛋白。
Mol Cell Biol. 1997 Dec;17(12):7019-28. doi: 10.1128/MCB.17.12.7019.
5
TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein.转化生长因子β诱导的Smad3磷酸化调节其与共激活因子p300/CREB结合蛋白的相互作用。
Mol Biol Cell. 1998 Dec;9(12):3309-19. doi: 10.1091/mbc.9.12.3309.
6
Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.人类I型T细胞白血病病毒癌蛋白Tax通过与CREB结合蛋白/p300相互作用抑制Smad依赖的转化生长因子β信号传导。
Blood. 2001 Apr 1;97(7):2137-44. doi: 10.1182/blood.v97.7.2137.
7
Role of p300, a transcriptional coactivator, in signalling of TGF-beta.转录共激活因子p300在转化生长因子β信号传导中的作用。
Genes Cells. 1998 Sep;3(9):613-23. doi: 10.1046/j.1365-2443.1998.00217.x.
8
The transcriptional co-activator P/CAF potentiates TGF-beta/Smad signaling.转录共激活因子P/CAF增强转化生长因子-β/ Smad信号传导。
Nucleic Acids Res. 2000 Nov 1;28(21):4291-8. doi: 10.1093/nar/28.21.4291.
9
Physical and functional interaction of SMADs and p300/CBP.SMAD 与 p300/CBP 的物理及功能相互作用。
J Biol Chem. 1998 Sep 4;273(36):22865-8. doi: 10.1074/jbc.273.36.22865.
10
Transforming growth factor-beta repression of matrix metalloproteinase-1 in dermal fibroblasts involves Smad3.转化生长因子-β对真皮成纤维细胞中基质金属蛋白酶-1的抑制作用涉及Smad3。
J Biol Chem. 2001 Oct 19;276(42):38502-10. doi: 10.1074/jbc.M107081200. Epub 2001 Aug 13.
引用本文的文献
1
SMAD3 and p300 complex scaffolding by long non-coding RNA LIMD1-AS1 promotes TGF-β-induced breast cancer cell plasticity.长链非编码RNA LIMD1-AS1介导的SMAD3与p300复合物支架促进TGF-β诱导的乳腺癌细胞可塑性。
Nucleic Acids Res. 2025 Aug 27;53(16). doi: 10.1093/nar/gkaf841.
2
Proteasomal processing of the viral replicase ORF1 facilitates HEV-induced liver fibrosis.病毒复制酶开放阅读框1的蛋白酶体加工促进戊型肝炎病毒诱导的肝纤维化。
Proc Natl Acad Sci U S A. 2025 Mar 18;122(11):e2419946122. doi: 10.1073/pnas.2419946122. Epub 2025 Mar 12.
3
Pistacia lentiscus L. revealed in vitro anti-proliferative activity on MCF-7 breast cancer cells and in vivo anti-mammary cancer effect on C57BL/6 mice through necrosis, anti-inflammatory and antioxidant enhancements.乳香黄连木（Pistacia lentiscus L.）通过促进细胞坏死、抗炎和抗氧化作用，显示出对 MCF-7 乳腺癌细胞的体外增殖抑制活性，以及对 C57BL/6 小鼠的体内抗乳腺癌作用。
PLoS One. 2024 Apr 18;19(4):e0301524. doi: 10.1371/journal.pone.0301524. eCollection 2024.
4
Targeting SMAD-Dependent Signaling: Considerations in Epithelial and Mesenchymal Solid Tumors.靶向SMAD依赖信号传导：上皮性和间叶性实体瘤的相关考量
Pharmaceuticals (Basel). 2024 Mar 1;17(3):326. doi: 10.3390/ph17030326.
5
TGF-β signaling in health, disease, and therapeutics.TGF-β 信号在健康、疾病和治疗中的作用。
Signal Transduct Target Ther. 2024 Mar 22;9(1):61. doi: 10.1038/s41392-024-01764-w.
6
SET8 is a novel negative regulator of TGF-β signaling in a methylation-independent manner.SET8 通过非甲基化依赖的方式成为 TGF-β 信号的新型负调控因子。
Sci Rep. 2023 Dec 18;13(1):22877. doi: 10.1038/s41598-023-49961-x.
7
SMAD Proteins in TGF-β Signalling Pathway in Cancer: Regulatory Mechanisms and Clinical Applications.癌症中TGF-β信号通路中的SMAD蛋白：调控机制与临床应用
Diagnostics (Basel). 2023 Aug 26;13(17):2769. doi: 10.3390/diagnostics13172769.
8
SNIP1 and PRC2 coordinate cell fates of neural progenitors during brain development.SNIP1 和 PRC2 在大脑发育过程中协调神经祖细胞的命运。
Nat Commun. 2023 Aug 8;14(1):4754. doi: 10.1038/s41467-023-40487-4.
9
Imatinib blocks tyrosine phosphorylation of Smad4 and restores TGF-β growth-suppressive signaling in BCR-ABL1-positive leukemia.伊马替尼抑制 Smad4 的酪氨酸磷酸化，并恢复 BCR-ABL1 阳性白血病中的 TGF-β 生长抑制信号。
Signal Transduct Target Ther. 2023 Mar 24;8(1):120. doi: 10.1038/s41392-023-01327-5.
10
Virtual screening for small-molecule pathway regulators by image-profile matching.基于图像轮廓匹配的小分子通路调节剂虚拟筛选
Cell Syst. 2022 Sep 21;13(9):724-736.e9. doi: 10.1016/j.cels.2022.08.003. Epub 2022 Sep 2.
本文引用的文献
1
The p300/CBP family: integrating signals with transcription factors and chromatin.p300/CBP 家族：将信号与转录因子和染色质整合在一起。
Trends Cell Biol. 1997 Jun;7(6):230-6. doi: 10.1016/S0962-8924(97)01048-9.
2
TGF-beta signalling through the Smad pathway.TGF-β 通过 Smad 通路进行信号转导。
Trends Cell Biol. 1997 May;7(5):187-92. doi: 10.1016/S0962-8924(97)01036-2.
3
Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads.多种转化生长因子-β信号的细胞解读：由Smads介导的激活素/BVg1与骨形态发生蛋白-2/4信号之间的细胞内拮抗作用
Development. 1997 Nov;124(22):4467-80. doi: 10.1242/dev.124.22.4467.
4
TGF-beta receptor signaling.转化生长因子-β受体信号传导
Biochim Biophys Acta. 1997 Oct 24;1333(2):F105-50. doi: 10.1016/s0304-419x(97)00017-6.
5
TGF-beta signalling from cell membrane to nucleus through SMAD proteins.转化生长因子-β（TGF-β）通过SMAD蛋白从细胞膜向细胞核传递信号。
Nature. 1997 Dec 4;390(6659):465-71. doi: 10.1038/37284.
6
Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein.肿瘤抑制因子Smad4是一种转化生长因子β诱导型DNA结合蛋白。
Mol Cell Biol. 1997 Dec;17(12):7019-28. doi: 10.1128/MCB.17.12.7019.
7
Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling.Smad2 C末端的丝氨酸465和丝氨酸467磷酸化介导与Smad4的相互作用，是转化生长因子-β信号传导所必需的。
J Biol Chem. 1997 Oct 31;272(44):28107-15. doi: 10.1074/jbc.272.44.28107.
8
TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling.Smad2-Smad4复合物形成及信号传导需要TbetaRI将Smad2的丝氨酸465和丝氨酸467磷酸化。
J Biol Chem. 1997 Oct 31;272(44):27678-85. doi: 10.1074/jbc.272.44.27678.
9
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4.转化生长因子-β受体介导的通过Smad2、Smad3和Smad4的信号传导。
EMBO J. 1997 Sep 1;16(17):5353-62. doi: 10.1093/emboj/16.17.5353.
10
Smad4 and FAST-1 in the assembly of activin-responsive factor.Smad4与FAST-1在激活素反应因子组装中的作用
Nature. 1997 Sep 4;389(6646):85-9. doi: 10.1038/38008.
Zotero 插件