Wang Qi, Xiong Fei, Wu Guanhua, Wang Da, Liu Wenzheng, Chen Junsheng, Qi Yongqiang, Wang Bing, Chen Yongjun
Department of Biliary-Pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.
Key Laboratory of Laparoscopic Technology of Zhejiang Province, Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
Diagnostics (Basel). 2023 Aug 26;13(17):2769. doi: 10.3390/diagnostics13172769.
Suppressor of mother against decapentaplegic (SMAD) family proteins are central to one of the most versatile cytokine signalling pathways in metazoan biology, the transforming growth factor-β (TGF-β) pathway. The TGF-β pathway is widely known for its dual role in cancer progression as both an inhibitor of tumour cell growth and an inducer of tumour metastasis. This is mainly mediated through SMAD proteins and their cofactors or regulators. SMAD proteins act as transcription factors, regulating the transcription of a wide range of genes, and their rich post-translational modifications are influenced by a variety of regulators and cofactors. The complex role, mechanisms, and important functions of SMAD proteins in tumours are the hot topics in current oncology research. In this paper, we summarize the recent progress on the effects and mechanisms of SMAD proteins on tumour development, diagnosis, treatment and prognosis, and provide clues for subsequent research on SMAD proteins in tumours.
母亲针对截瘫的抑制因子（SMAD）家族蛋白是后生动物生物学中最通用的细胞因子信号通路之一——转化生长因子-β（TGF-β）通路的核心。TGF-β通路因其在癌症进展中的双重作用而广为人知，它既是肿瘤细胞生长的抑制剂，又是肿瘤转移的诱导剂。这主要是通过SMAD蛋白及其辅因子或调节剂介导的。SMAD蛋白作为转录因子，调节多种基因的转录，其丰富的翻译后修饰受多种调节剂和辅因子的影响。SMAD蛋白在肿瘤中的复杂作用、机制和重要功能是当前肿瘤学研究的热点。在本文中，我们总结了SMAD蛋白对肿瘤发生、诊断、治疗和预后的影响及机制的最新进展，并为后续关于SMAD蛋白在肿瘤中的研究提供线索。
