Nestadt G, Bienvenu O J, Cai G, Samuels J, Eaton W W
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University, Baltimore, Maryland 21287-7481, USA.
J Nerv Ment Dis. 1998 Jul;186(7):401-6. doi: 10.1097/00005053-199807000-00003.
This study addressed the incidence of obsessive-compulsive disorder (OCD) in adults in the general population. The Baltimore cohort of 3481 subjects, originally sampled during the 1981 multisite Epidemiologic Catchment Area Study, was traced. From 1993 to 1996, 1920 people were reinterviewed using the Diagnostic Interview Schedule. The incidence of DSM-III-R obsessive-compulsive disorder in adults was estimated at .55 per 1000 person-years. There was a relatively high rate of new cases in elderly women. It appeared that there were two peaks of onset of OCD over the life span, both of which occur later in female subjects. Subjects with adult incidence OCD often presented for psychiatric treatment, though they did not specify obsessive-compulsive symptoms as the reason. The difference in diagnostic criteria between DSM-III and DSM-III-R substantially influenced the threshold for new case identification.
本研究探讨了普通人群中成年人强迫症（OCD）的发病率。对最初在1981年多地点流行病学集水区研究中抽样的3481名巴尔的摩受试者组成的队列进行了追踪。1993年至1996年期间，使用诊断访谈表对1920人进行了再次访谈。成年人中DSM-III-R强迫症的发病率估计为每1000人年0.55例。老年女性的新发病例率相对较高。似乎在整个生命周期中强迫症有两个发病高峰，且两个高峰在女性受试者中出现得更晚。成年期发病的强迫症患者经常寻求精神科治疗，尽管他们并未将强迫症状作为就诊原因。DSM-III和DSM-III-R之间诊断标准的差异极大地影响了新病例识别的阈值。
