Yu M, Deming TJ
Departments of Materials and Chemistry, University of California, Santa Barbara, Santa Barbara, California 93106.
Macromolecules. 1998 Jul 28;31(15):4739-45. doi: 10.1021/ma980268z.
Water soluble copolypeptides containing l-dihydroxyphenylalanine (DOPA) and l-lysine were prepared by ring-opening polymerization of alpha-amino acid N-carboxyanhydride (NCA) monomers. We have prepared a range of different copolymers to probe the effects of functional group composition on adhesive and cross-linking behavior. Aqueous solutions of these copolymers, when mixed with a suitable oxidizing agent (e.g., O2, mushroom tyrosinase, Fe3+, H2O2, or IO4-), formed cross-linked networks that were found to form moisture-resistant adhesive bonds to a variety of substrates (e.g., aluminum, steel, glass, and plastics). It was found that successful adhesive formation was dependent on oxidation conditions, with chemical oxidants giving the best results. Optimized systems were found to form adhesive bonds that rival in strength those formed by natural marine adhesive proteins. Our synthetic systems are readily prepared in large quantities and require no enzymes or other biological components.
通过α-氨基酸N-羧基酸酐（NCA）单体的开环聚合反应制备了含有L-二羟基苯丙氨酸（DOPA）和L-赖氨酸的水溶性共聚多肽。我们制备了一系列不同的共聚物，以探究官能团组成对粘附和交联行为的影响。这些共聚物的水溶液与合适的氧化剂（例如O2、蘑菇酪氨酸酶、Fe3+、H2O2或IO4-）混合时，会形成交联网络，发现该网络能与多种基材（例如铝、钢、玻璃和塑料）形成防潮粘合。结果发现，成功形成粘合剂取决于氧化条件，化学氧化剂效果最佳。优化后的体系形成的粘合强度可与天然海洋粘合蛋白形成的粘合强度相媲美。我们的合成体系易于大量制备，无需酶或其他生物成分。
