Zhao Wenxiang, Hu Chuxiong, Xu Tao
State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing, 100084, China.
Beijing Key Laboratory of Precision/Ultra-Precision Manufacturing Equipments and Control, Tsinghua University, Beijing, 100084, China.
Bioact Mater. 2023 Feb 6;25:201-222. doi: 10.1016/j.bioactmat.2023.01.018. eCollection 2023 Jul.
Tissue injury is a collective term for various disorders associated with organs and tissues induced by extrinsic or intrinsic factors, which significantly concerns human health. bioprinting, an emerging tissue engineering approach, allows for the direct deposition of bioink into the defect sites inside the patient's body, effectively addressing the challenges associated with the fabrication and implantation of irregularly shaped scaffolds and enabling the rapid on-site management of tissue injuries. This strategy complements operative therapy as well as pharmacotherapy, and broadens the therapeutic horizon for tissue injuries. The implementation of bioprinting requires targeted investigations in printing modalities, bioinks, and devices to accommodate the unique intracorporal microenvironment, as well as effective integrations with intraoperative procedures to facilitate its clinical application. In this review, we summarize the developments of bioprinting from three perspectives: modalities and bioinks, devices, and clinical integrations, and further discuss the current challenges and potential improvements in the future.
组织损伤是一个统称，指由外在或内在因素引起的与器官和组织相关的各种病症，这严重关乎人类健康。生物打印作为一种新兴的组织工程方法，能够将生物墨水直接沉积到患者体内的缺损部位，有效应对与不规则形状支架的制造和植入相关的挑战，并实现对组织损伤的快速现场处理。该策略补充了手术治疗和药物治疗，拓宽了组织损伤的治疗视野。生物打印的实施需要针对打印方式、生物墨水和设备进行有针对性的研究，以适应独特的体内微环境，还需要与术中程序进行有效整合以促进其临床应用。在本综述中，我们从三个角度总结生物打印的发展：方式和生物墨水、设备以及临床整合，并进一步讨论当前的挑战和未来可能的改进。
