Petritsch W, Feichtenschlager T, Gasche C, Hinterleitner T, Judmaier G, Knoflach P, Moser G, Offner F, Peer G, Simbrunner I
Klinischen Abteilung für Gastroenterologie und Hepatologie, Medizinischen Universitätsklinik Graz.
Acta Med Austriaca. 1998;25(2):37-43.
Diagnostic procedures in inflammatory bowel diseases (IBD) serve to secure the diagnosis and to optimize treatment. Upon initial diagnosis endoscopy up to the terminal ileum is mandatory including multiple step biopsies. When diagnostic guidelines are followed and adequate clinical information is available, IBD will be correctly classified in about 80 to 90% of cases upon first examination. In contrast endoscopic studies are only of limited value in monitoring treatment. The decision if and when to perform endoscopy during exacerbation of disease must be an individual one. When disease activity is evaluated, a distinction must be made between degree of activity as reflected by laboratory parameters and severity of illness as reflected by the clinical presentation with abdominal complaints, fistulas, abscesses, etc. Distinct activity indices are useful in clinical studies to obtain an objective evaluation of activity and severity of disease. At clinical routine visits questions should not only concern the basic illness but also ask for quality of life and psychosocial status. Only a small number of laboratory tests are needed for basic diagnosis and follow-up. A small bowel enteroclysis should always be performed upon primary diagnosis of Crohn's disease and during the course of disease when there is suspicion of small-bowel involvement. Double contrast barium enema should be limited to special indications as incomplete colonoscopy e.g. due to stenosis or suspected fistula. Sonography is the primary investigation when complications are suspected. CT is useful as an adjunct or when the afore mentioned methods do not show clear findings. NMR is the procedure of choice for detection of pararectal fistulas and abscesses. Transrectal endosonography is comparably good but limited to the experience of the investigators and by patient's tolerability.
炎症性肠病(IBD)的诊断程序有助于确诊并优化治疗。初次诊断时,必须进行直至回肠末端的内镜检查,并进行多次分步活检。当遵循诊断指南并获得充分的临床信息时,约80%至90%的病例在首次检查时就能正确分类为IBD。相比之下,内镜检查在监测治疗方面的价值有限。在疾病发作期间是否以及何时进行内镜检查的决定必须因人而异。评估疾病活动时,必须区分实验室参数所反映的活动程度和临床表现(如腹部不适、瘘管、脓肿等)所反映的疾病严重程度。在临床研究中,特定的活动指数有助于对疾病的活动和严重程度进行客观评估。在临床常规就诊时,问题不仅应涉及基础疾病,还应询问生活质量和心理社会状况。基础诊断和随访仅需少量实验室检查。克罗恩病初次诊断时以及病程中怀疑小肠受累时,应始终进行小肠灌肠造影。双重对比钡剂灌肠应限于特殊指征,如结肠镜检查不完整(如由于狭窄或怀疑有瘘管)。怀疑有并发症时,超声检查是主要的检查方法。CT作为辅助检查或上述方法未显示明确结果时很有用。核磁共振成像(NMR)是检测直肠旁瘘管和脓肿的首选检查方法。经直肠超声内镜检查效果相当不错,但受检查者经验和患者耐受性的限制。