Tachibana M, Murai M
Department of Urology, School of Medicine, Keio University, Japan.
Cytokines Cell Mol Ther. 1998 Jun;4(2):113-20.
A variety of non-hematopoietic malignant tumors have been demonstrated to secrete granulocyte colony-stimulating factor (G-CSF) in amounts large enough to cause a significant systemic hematopoietic effect. Meanwhile, bladder cancer cells have been shown to secrete a variety of biological factors with no direct relation to urothelial cell origin. G-CSF produced by non-hematopoietic malignant cells in particular has been reported to be capable of inducing a leukemoid reaction in the host through intense stimulation of leukocyte production. This is most frequently associated with aggressive tumor cell growth and a poor clinical outcome. On the other hand, receptors for G-CSF have also been found on the cell surfaces of several non-hematopoietic cell types. These observations lead naturally to the tempting speculation that simultaneous acquisition of the ligand promotion and its receptor expression by a malignant tumor may provide a strong autocrine growth advantage. However, the role of autocrine growth factors in malignancy is even less clear, although it is undoubtedly important. In this review, G-CSF and tumor cell growth, particularly of human transitional cell carcinomas of the bladder, are discussed, and autocrine growth of human solid tumors is also summarized.
多种非造血系统恶性肿瘤已被证实可分泌大量粒细胞集落刺激因子（G-CSF），足以引起显著的全身造血效应。同时，膀胱癌细胞已被证明可分泌多种与尿路上皮细胞起源无直接关系的生物因子。特别是非造血系统恶性细胞产生的G-CSF据报道能够通过强烈刺激白细胞生成在宿主体内诱导类白血病反应。这最常与侵袭性肿瘤细胞生长和不良临床结局相关。另一方面，在几种非造血细胞类型的细胞表面也发现了G-CSF受体。这些观察结果自然引发了一种诱人的推测，即恶性肿瘤同时获得配体促进及其受体表达可能提供强大的自分泌生长优势。然而，自分泌生长因子在恶性肿瘤中的作用甚至更不清楚，尽管它无疑很重要。在这篇综述中，讨论了G-CSF与肿瘤细胞生长，特别是膀胱移行细胞癌的生长，并总结了人类实体瘤的自分泌生长。
