对阿根廷与麻风病患者密切接触者的疫苗接种研究。

Studies of vaccination of persons in close contact with leprosy patients in Argentina.

作者信息

Bottasso O, Merlin V, Cannon L, Cannon H, Ingledew N, Keni M, Hartopp R, Stanford C, Stanford J

机构信息

Instituto de Inmunologia, Facultad de Ciencias Medicas, Universidad Nacional de Rosario, Argentina.

出版信息

Vaccine. 1998 Jul;16(11-12):1166-71. doi: 10.1016/s0264-410x(98)80115-1.

DOI:10.1016/s0264-410x(98)80115-1

PMID:9682375

Abstract

A total of 670 adults living or working with leprosy patients, were examined for a BCG vaccination scar, and skin-tested with four new tuberculins. Based on the results 513 were vaccinated, 65 with Bacille de Calmette et Guérin (BCG) alone, 66 with BCG plus killed Mycobacterium vaccae and 382 with killed M. vaccae alone. Skin-testing was repeated 2-3 years later on 344 subjects, when all three vaccines were found to have been highly successful in increasing responses to Tuberculin and Leprosin A (p < 0.0005) with increased immune recognition of common and species-specific antigens. Mean diameters of induration to each skin-test were greatest in recipients of BCG alone (p < 0.05), which suggests that better immuno-regulation occurs after receiving vaccines that incorporate M. vaccae. The results suggest 10(8) M. vaccae alone might prove a valuable future vaccine, which would not require selective pre-vaccination procedures.

摘要

共有670名与麻风病人生活或工作在一起的成年人接受了卡介苗接种疤痕检查，并用四种新型结核菌素进行了皮肤测试。根据测试结果，513人接种了疫苗，其中65人仅接种了卡介苗（BCG），66人接种了卡介苗加灭活的母牛分枝杆菌，382人仅接种了灭活的母牛分枝杆菌。2至3年后，对344名受试者再次进行皮肤测试，结果发现所有三种疫苗在增强对结核菌素和麻风菌素A的反应方面都非常成功（p < 0.0005），对共同抗原和种特异性抗原的免疫识别也有所增强。仅接种卡介苗的受试者对每次皮肤测试的硬结平均直径最大（p < 0.05），这表明接种含有母牛分枝杆菌的疫苗后免疫调节效果更好。结果表明，仅10(8)个灭活的母牛分枝杆菌可能会成为一种有价值的未来疫苗，这种疫苗不需要选择性的预接种程序。