Nikolova Nevena, Ivanova Donika, Yaneva Zvezdelina
Ecology with Radioecology Unit, Department of General Livestock Breeding, Faculty of Veterinary Medicine, Students Campus, Trakia University, 6000 Stara Zagora, Bulgaria.
Chemistry Unit, Department of Pharmacology, Animal Physiology, Biochemistry and Chemistry, Faculty of Veterinary Medicine, Students Campus, Trakia University, 6000 Stara Zagora, Bulgaria.
Life (Basel). 2022 Feb 26;12(3):346. doi: 10.3390/life12030346.
The aim of the present study was to investigate the radioprotective activity of silymarin, a plant substance with hepatoprotective activity, of four newly synthesized structural derivatives of anthranilic acid azomethines, and alkyl-2-styrylquinolinic acid, as well as to establish and assess the influence of the solvent type and bioactive compound dose on the in vivo radioprotective potential of the natural and novel synthetic compounds. Male Wistar strain rats weighing 110-120 g were used for the in vivo experiments. Fifteen minutes after i.p. injection of the compounds, the experimental animals were irradiated by 8 Gy. Results indicate that the compound 2-{[(3,5-dihydro-2-hydroxyphenyl)methylen] amino}-benzoic acid in a dose of 60 mg/kg body weight exhibited the highest radioprotective effect, whereas the natural extract silymarin did not manifest radioprotective potential, even in high doses.
本研究的目的是研究水飞蓟素（一种具有肝脏保护活性的植物物质）、四种新合成的邻氨基苯甲酸偶氮甲碱结构衍生物以及烷基-2-苯乙烯基喹啉酸的辐射防护活性，并确定和评估溶剂类型和生物活性化合物剂量对天然和新型合成化合物体内辐射防护潜力的影响。体重110 - 120克的雄性Wistar品系大鼠用于体内实验。腹腔注射化合物15分钟后，对实验动物进行8 Gy的照射。结果表明，剂量为60毫克/千克体重的化合物2-{[(3,5-二氢-2-羟基苯基)亚甲基]氨基}-苯甲酸表现出最高的辐射防护效果，而天然提取物水飞蓟素即使在高剂量下也未表现出辐射防护潜力。
