Watabe K, Nishi M, Miyake H, Hirata K
First Department of Surgery, Sapporo Medical University, Sapporo, Hokkaido, Japan.
Oncol Rep. 1998 Sep-Oct;5(5):1191-4. doi: 10.3892/or.5.5.1191.
In Hokkaido, Japan, in order to investigate the etiological relation between gastric cancer and lifestyle, a case-control study was conducted, employing 242 cases with this cancer and 484 controls matched for sex, age, and place of residence. Eating meals within a short time, eating until full, irregularity in the time for supper, having dentures, and lack of teeth showed high odds ratios. Putting an excess digestive burden on the stomach by insufficient chewing promotes the development of this cancer. Stress, long working time, irregularity in sleeping time, and gray hair in males showed high odds ratios. A stressful life may be promotive for this cancer through depressed immunoresistance. Logistic regression analysis showed that those who ate meals rapidly, had strong stress and had lost many teeth were at high risk. The linear trend of the dose-response relationship between the number of teeth lost and the odds ratio was highly significant. To avoid stress, to chew foods sufficiently, and to maintain the health of the oral cavity can help to prevent gastric cancer.
在日本北海道，为了调查胃癌与生活方式之间的病因关系，开展了一项病例对照研究，研究采用了242例胃癌患者以及484例在性别、年龄和居住地点方面相匹配的对照。吃饭用时短、吃到饱、晚餐时间不规律、戴假牙以及牙齿缺失显示出较高的比值比。咀嚼不足给胃部带来过多消化负担会促进这种癌症的发展。压力、工作时间长、睡眠时间不规律以及男性头发变白显示出较高的比值比。压力大的生活可能通过免疫抵抗力下降促进这种癌症的发生。逻辑回归分析表明，吃饭快、压力大以及牙齿缺失多的人风险较高。牙齿缺失数量与比值比之间的剂量反应关系的线性趋势非常显著。避免压力、充分咀嚼食物以及保持口腔健康有助于预防胃癌。
