Kwon Mi Jung, Kang Ho Suk, Kim Min-Jeong, Kim Nan Young, Choi Hyo Geun, Lim Hyun
Department of Pathology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of Korea.
Division of Gastroenterology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of Korea.
Cancers (Basel). 2023 Aug 4;15(15):3974. doi: 10.3390/cancers15153974.
There is limited information regarding the potential association between chronic periodontitis (CP) and gastric cancer, especially in the Korean population. This study aimed to explore this relationship. This nested case-control study analyzed data from 10,174 patients with gastric cancer and 40,696 controls from the Korean National Health Insurance Service-National Sample Cohort using propensity score matching. Standardized differences were used to compare baseline characteristics between study groups. Logistic regression analyses adjusted for confounders were conducted to assess the association between history of CP and gastric cancer occurrence. CP histories and comprehensive subgroup analyses in the 1- and 2-year periods preceding the index date were evaluated. Individuals with a history of CP within the 1-year and 2-year periods showed an increased likelihood of developing gastric cancer. Subgroup analyses consistently supported these findings in male participants aged <65 years and individuals with various income levels or living in residential areas. However, no significant associations were observed among participants aged ≥65 years. In conclusion, CP may be a potential risk factor for gastric cancer development in the Korean population. Regular screening for gastric cancer may be necessary for high-risk individuals, specifically men aged <65 years with a history of CP.
关于慢性牙周炎（CP）与胃癌之间的潜在关联，相关信息有限，尤其是在韩国人群中。本研究旨在探讨这种关系。这项巢式病例对照研究使用倾向得分匹配法，分析了来自韩国国民健康保险服务全国样本队列的10174例胃癌患者和40696例对照的数据。采用标准化差异来比较研究组之间的基线特征。进行了调整混杂因素的逻辑回归分析，以评估CP病史与胃癌发生之间的关联。评估了索引日期前1年和2年内的CP病史及综合亚组分析。在1年和2年内有CP病史的个体患胃癌的可能性增加。亚组分析在年龄<65岁的男性参与者以及不同收入水平或居住地区的个体中一致支持了这些发现。然而，在年龄≥65岁的参与者中未观察到显著关联。总之，在韩国人群中，CP可能是胃癌发生的一个潜在危险因素。对于高危个体，特别是有CP病史的<65岁男性，可能有必要定期进行胃癌筛查。
