过敏性结膜炎患者的泪液免疫球蛋白E浓度

Tear IgE concentrations in allergic conjunctivitis.

作者信息

Nomura K, Takamura E

机构信息

Department of Ophthalmology, Tokyo Women's Medical College, Japan.

出版信息

Eye (Lond). 1998;12 ( Pt 2):296-8. doi: 10.1038/eye.1998.68.

DOI:10.1038/eye.1998.68

PMID:9683958

Abstract

PURPOSE

Tear IgE has been considered to play an important role in allergic conjunctivitis and the measurement of tear IgE concentrations can help to diagnose this condition. Locally produced IgE levels have been shown to be the largest contributor to the severity of allergic conjunctivitis.

METHODS

One hundred and thirteen allergic conjunctivitis patients (70 seasonal allergic conjunctivitis (SAC), 21 perennial allergic conjunctivitis (PAC), 22 vernal keratoconjunctivitis (VKC)), 14 bacterial conjunctivitis (BC) patients, 13 epidemic keratoconjunctivitis (EKC) patients and 18 normal controls were recruited. Tear samples were collected using the microcapillary method and tear IgE levels were measured using an immunoenzyme assay.

RESULTS

Tear IgE concentrations showed significant increases in the VKC (322.2 +/- 45.7 ng/ml), SAC (194.7 +/- 21.7 ng/ml) and PAC (134.8 +/- 23.1 ng/ml) groups when compared with controls (52.1 +/- 9.7 ng/ml, p < 0.01). No significant difference was found between EKC (97.2 +/- 11.7 ng/ml) and BC (92.6 +/- 13.8 ng/ml) groups and controls (p = 0.1).

CONCLUSIONS

Tear IgE concentrations showed a significant increase in allergic conjunctivitis patients when compared with controls. Our results suggest that measuring tear IgE concentrations can help to diagnose allergic conjunctivitis.

摘要

目的

泪液免疫球蛋白E（IgE）被认为在过敏性结膜炎中起重要作用，测量泪液IgE浓度有助于诊断这种疾病。局部产生的IgE水平已被证明是过敏性结膜炎严重程度的最大影响因素。

方法

招募了113例过敏性结膜炎患者（70例季节性过敏性结膜炎（SAC）、21例常年性过敏性结膜炎（PAC）、22例春季角结膜炎（VKC））、14例细菌性结膜炎（BC）患者、13例流行性角结膜炎（EKC）患者和18名正常对照者。使用微量毛细管法收集泪液样本，并采用免疫酶测定法测量泪液IgE水平。

结果

与对照组（52.1±9.7 ng/ml，p<0.01）相比，VKC组（322.2±45.7 ng/ml）、SAC组（194.7±21.7 ng/ml）和PAC组的泪液IgE浓度显著升高。EKC组（97.2±11.7 ng/ml）和BC组（92.6±13.8 ng/ml）与对照组之间未发现显著差异（p = 0.1）。