Gasbarrini A, De Luca A, Fiore G, Gambrielli M, Franceschi F, Ojetti V, Torre E S, Gasbarrini G, Pola P, Giacovazzo M
Angiology Department, Catholic University, Rome, Italy.
Hepatogastroenterology. 1998 May-Jun;45(21):765-70.
BACKGROUND/AIMS: Migraine is a commonly unilateral throbbing headache, which has been associated with disorders of the vascular tone. Helicobacter pylori, the most relevant cause of gastritis and peptic ulcer, has been recently associated with a typical functional vascular disorder such as primary Raynaud phenomenon. The aim of this study was to assess the prevalence of H. pylori for patients affected by migraine and the effects of H. pylori eradication on migraine symptoms.
Two-hundred and twenty-five patients were consecutively enrolled between October 1996 and January 1997. H. pylori was assessed by 13C-urea breath test. Infected subjects were eradicated of the bacterium; frequency, intensity and duration of attacks of migraine were assessed during a 6 month follow-up period.
H. pylori was detected in 40% of the patients. Eighty-three percent of the patients who underwent therapy were eradicated. Intensity, duration and frequency of attacks of migraine were significantly reduced in all eradicated patients.
H. pylori is common in subjects with migraine. Bacterium eradication causes a significant decrease in attacks of migraine. The reduction of vasoactive substances produced during infection may be the pathogenetic mechanism underlying the phenomenon.
背景/目的：偏头痛是一种常见的单侧搏动性头痛，与血管张力紊乱有关。幽门螺杆菌是胃炎和消化性溃疡最主要的病因，最近它被认为与一种典型的功能性血管疾病，如原发性雷诺现象有关。本研究的目的是评估偏头痛患者中幽门螺杆菌的患病率，以及根除幽门螺杆菌对偏头痛症状的影响。
1996年10月至1997年1月连续纳入225例患者。通过13C-尿素呼气试验评估幽门螺杆菌。对感染患者进行细菌根除治疗；在6个月的随访期内评估偏头痛发作的频率、强度和持续时间。
40%的患者检测出幽门螺杆菌。接受治疗的患者中83%根除了幽门螺杆菌。所有根除幽门螺杆菌的患者偏头痛发作的强度、持续时间和频率均显著降低。
幽门螺杆菌在偏头痛患者中很常见。根除细菌可使偏头痛发作显著减少。感染期间产生的血管活性物质减少可能是这一现象的发病机制。
