Pelliniemi T T, Viikari J, Nieminen L
Scand J Haematol. 1976 Aug;17(2):117-22. doi: 10.1111/j.1600-0609.1976.tb01164.x.
Lipids of rat plasma and erythrocytes were analysed during hyperlipidaemic diet and clofibrate treatment. The diet increased the plasma cholesterol and phospholipid concentrations after 3 weeks' lipid feeding. Clofibrate in a dose of 200 mg/kg body weight did not inhibit the increase in plasma cholesterol and phospholipid contents, but significantly decreased the concentration of plasma triglycerides. The lipid diet slightly increased the erythrocyte cholesterol and phospholipid concentrations without affecting the red cell morphology or reticulocytosis. After 1 week's treatment, clofibrate in a dose of 200 mg/kg body weight caused a 2-fold increase in the cholesterol content and a rise in the cholesterol-phospholipid ratio of red blood cells of rats fed the hyperlipidaemic diet. These results suggest that the erythrocyte cell membrane can increase its cholesterol content and possibly play a role in cholesterol transport.
在高脂血症饮食和氯贝丁酯治疗期间，对大鼠血浆和红细胞的脂质进行了分析。在进行3周的脂质喂养后，该饮食增加了血浆胆固醇和磷脂浓度。剂量为200mg/kg体重的氯贝丁酯并未抑制血浆胆固醇和磷脂含量的增加，但显著降低了血浆甘油三酯的浓度。脂质饮食略微增加了红细胞胆固醇和磷脂浓度，而未影响红细胞形态或网织红细胞增多。在1周的治疗后，剂量为200mg/kg体重的氯贝丁酯使喂食高脂血症饮食的大鼠红细胞胆固醇含量增加了2倍，并使胆固醇-磷脂比值升高。这些结果表明，红细胞细胞膜可以增加其胆固醇含量，并可能在胆固醇转运中发挥作用。
