Norrby R, Stenqvist K, Elgefors B
Scand J Infect Dis. 1976;8(3):209-12. doi: 10.3109/inf.1976.8.issue-3.17.
The effect of a moderate oral dose of furosemide (80 mg daily) on the serum half-life of cephaloridine was studied. In 14 patients not previously treated with diuretics this dose was found to prolong the half-life significantly. A corresponding decrease of the half-life of cephaloridine was observed when furosemide was withdrawn from 2 patients who were treated with diuretics at admission to hospital. The concurrent treatment with furosemide and cephaloridine did not affect the renal function of the patients studied. From the results obtained it seems possible that even moderate doses of a potent diuretic increase the nephrotoxicity of a cephalosporin.
研究了中等口服剂量速尿（每日80毫克）对头孢菌素血清半衰期的影响。在14名未接受过利尿剂治疗的患者中，发现该剂量可显著延长半衰期。当对2名入院时接受利尿剂治疗的患者停用速尿时，观察到头孢菌素半衰期相应缩短。速尿和头孢菌素同时治疗对所研究患者的肾功能无影响。从获得的结果来看，即使是中等剂量的强效利尿剂似乎也会增加头孢菌素的肾毒性。
