Nanni O, Falcini F, Buiatti E, Bucchi L, Naldoni M, Serra P, Scarpi E, Saragoni L, Amadori D
Istituto Oncologico Romagnolo, Forlì, Italy.
Cancer Causes Control. 1998 May;9(3):277-83. doi: 10.1023/a:1008821119851.
To evaluate the relation between the exposure to specific pesticides in agricultural work and the risk of multiple myeloma (MM).
A case-control study was conducted in the province of Forlì, Italy. Forty-six cases of MM (20 females, 26 males; mean age 64 years, range 40 to 74) identified through the Romagna Cancer Registry in the years 1987-90, and 230 age- and gender-matched controls from the general population were interviewed in-person using a structured questionnaire focused on exposure to pesticides and other occupational and nonoccupational variables.
Among nonoccupational factors, the education level and the altitude of the place of residence were related inversely to MM risk. First-degree familiarity for hematolymphopoietic neoplasias and previous herpes zoster diagnosis were associated positively with the disease. A nonsignificant increase in MM risk was observed among workers in agriculture as a whole (odds ratio [OR] = 1.31, 95 percent confidence interval [CI] = 0.62-2.74). An increased risk was associated specifically with the cultivation of apples and pears (OR = 1.75, CI = 1.05-2.91). As regards pesticide exposure, only the chlorinated insecticides were related to an increase in the risk of MM.
This study suggests that agricultural work and exposure to pesticides have a role in the etiology of MM.
评估农业工作中接触特定农药与多发性骨髓瘤（MM）风险之间的关系。
在意大利弗利省进行了一项病例对照研究。通过拉马尼亚癌症登记处确定了1987 - 1990年间的46例MM患者（20名女性，26名男性；平均年龄64岁，范围40至74岁），并使用一份针对农药接触以及其他职业和非职业变量的结构化问卷，对来自普通人群的230名年龄和性别匹配的对照进行了面对面访谈。
在非职业因素中，教育水平和居住地点的海拔高度与MM风险呈负相关。血液淋巴系统肿瘤的一级亲属关系和先前的带状疱疹诊断与该疾病呈正相关。总体而言，农业工人中MM风险有不显著增加（优势比[OR]=1.31，95%置信区间[CI]=0.62 - 2.74）。风险增加具体与苹果和梨的种植相关（OR = 1.75，CI = 1.05 - 2.91）。关于农药接触，只有氯化杀虫剂与MM风险增加有关联。
本研究表明农业工作和农药接触在MM的病因中起作用。
