Scott R A, Tisi P V, Ashton H A, Allen D R
Department of Vascular Surgery, St. Richard's Hospital, Chichester, West Sussex, United Kingdom.
J Vasc Surg. 1998 Jul;28(1):124-8. doi: 10.1016/s0741-5214(98)70207-1.
The goal of the current study was to identify the risk of rupture in the entire abdominal aortic aneurysm (AAA) population detected through screening and to review strategies for surgical intervention in light of this information.
Two hundred eighteen AAAs were detected through ultrasound screening of a family practice population of 5394 men and women aged 65 to 80 years. Subjects with an AAA of less than 6.0 cm in diameter were followed prospectively with the use of ultrasound, according to our protocol, for 7 years. Patients were offered surgery if symptomatic, if the aneurysm expanded more than 1.0 cm per year, or if aortic diameter reached 6.0 cm.
The maximum potential rupture rate (actual rupture rate plus elective surgery rate) for small AAAs (3.0 to 4.4 cm) was 2.1% per year, which is less than most reported operative mortality rates. The equivalent rate for aneurysms of 4.5 to 5.9 cm was 10.2% per year. The actual rupture rate for aneurysms up to 5.9 cm using our criteria for surgery was 0.8% per year
In centers with an operative mortality rate of greater than 2%, (1) surgical intervention is not indicated for asymptomatic AAAs of less than 4.5 cm in diameter, and (2) elective surgery should be considered only for patients with aneurysms between 4.5 and 6 cm in diameter that are expanding by more than 1 cm per year or for patients in whom symptoms develop. In centers with elective mortality rates of greater than 10% for abdominal aortic aneurysm (AAA) repair, the benefit to the patient of any surgical intervention for an asymptomatic AAA of less than 6.0 cm in diameter is questionable.
本研究的目的是确定通过筛查检测出的整个腹主动脉瘤(AAA)人群的破裂风险,并根据这些信息回顾手术干预策略。
通过对5394名年龄在65至80岁的男女家庭医生诊疗人群进行超声筛查,检测出218例腹主动脉瘤。根据我们的方案,对直径小于6.0 cm的腹主动脉瘤患者进行前瞻性超声随访7年。如果患者出现症状、动脉瘤每年扩张超过1.0 cm或主动脉直径达到6.0 cm,则建议进行手术。
小腹主动脉瘤(3.0至4.4 cm)的最大潜在破裂率(实际破裂率加择期手术率)为每年2.1%,低于大多数报道的手术死亡率。4.5至5.9 cm动脉瘤的等效率为每年10.2%。根据我们的手术标准,直径达5.9 cm的动脉瘤的实际破裂率为每年0.8%。
在手术死亡率大于2%的中心,(1)对于直径小于4.5 cm的无症状腹主动脉瘤,不建议进行手术干预;(2)对于直径在4.5至6 cm之间且每年扩张超过1 cm的动脉瘤患者或出现症状的患者,应仅考虑择期手术。在腹主动脉瘤(AAA)修复择期死亡率大于10%的中心,对直径小于6.0 cm的无症状腹主动脉瘤进行任何手术干预对患者的益处值得怀疑。