Colavita A, Krishna S, Zheng H, Padgett R W, Culotti J G
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
Science. 1998 Jul 31;281(5377):706-9. doi: 10.1126/science.281.5377.706.
The unc-129 gene, like the unc-6 netrin gene, is required to guide pioneer motoraxons along the dorsoventral axis of Caenorhabditis elegans. unc-129 encodes a member of the transforming growth factor-beta (TGF-beta) superfamily of secreted signaling molecules and is expressed in dorsal, but not ventral, rows of body wall muscles. Ectopic expression of UNC-129 from ventral body wall muscle disrupts growth cone and cell migrations that normally occur along the dorsoventral axis. Thus, UNC-129 mediates expression of dorsoventral polarity information required for axon guidance and guided cell migrations in C. elegans.
与unc-6 netrin基因一样，unc-129基因是秀丽隐杆线虫背腹轴引导先驱运动轴突所必需的。unc-129编码分泌信号分子转化生长因子-β（TGF-β）超家族的一个成员，在体壁肌肉的背侧而非腹侧排中表达。从腹侧体壁肌肉异位表达UNC-129会破坏通常沿背腹轴发生的生长锥和细胞迁移。因此，UNC-129介导了秀丽隐杆线虫轴突导向和引导细胞迁移所需的背腹极性信息的表达。
