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Identification of the newly discovered 58 kDa peroxisomal thiolase SCPx as the main thiolase involved in both pristanic acid and trihydroxycholestanoic acid oxidation: implications for peroxisomal beta-oxidation disorders.

作者信息

Wanders R J, Denis S, van Berkel E, Wouters F, Wirtz K W, Seedorf U

机构信息

University of Amsterdam, Academic Medical Centre, Department of Clinical Chemistry, The Netherlands.

出版信息

J Inherit Metab Dis. 1998 Jun;21(3):302-5. doi: 10.1023/a:1005349028853.

DOI:10.1023/a:1005349028853
PMID:9686381
Abstract
摘要

相似文献

1
Identification of the newly discovered 58 kDa peroxisomal thiolase SCPx as the main thiolase involved in both pristanic acid and trihydroxycholestanoic acid oxidation: implications for peroxisomal beta-oxidation disorders.新发现的58 kDa过氧化物酶体硫解酶SCPx被鉴定为参与降植烷酸和三羟基胆甾烷酸氧化的主要硫解酶：对过氧化物酶体β-氧化障碍的影响
J Inherit Metab Dis. 1998 Jun;21(3):302-5. doi: 10.1023/a:1005349028853.
2
Sterol carrier protein X (SCPx) is a peroxisomal branched-chain beta-ketothiolase specifically reacting with 3-oxo-pristanoyl-CoA: a new, unique role for SCPx in branched-chain fatty acid metabolism in peroxisomes.固醇载体蛋白X（SCPx）是一种过氧化物酶体支链β-酮硫解酶，它特异性地与3-氧代-降植烷酰辅酶A反应：SCPx在过氧化物酶体支链脂肪酸代谢中的一种新的独特作用。
Biochem Biophys Res Commun. 1997 Jul 30;236(3):565-9. doi: 10.1006/bbrc.1997.7007.
3
Peroxisomal fatty acid oxidation disorders and 58 kDa sterol carrier protein X (SCPx). Activity measurements in liver and fibroblasts using a newly developed method.过氧化物酶体脂肪酸氧化障碍与58 kDa固醇载体蛋白X（SCPx）。使用新开发的方法对肝脏和成纤维细胞进行活性测量。
J Lipid Res. 2000 Mar;41(3):336-42.
4
Substrate specificities of 3-oxoacyl-CoA thiolase A and sterol carrier protein 2/3-oxoacyl-CoA thiolase purified from normal rat liver peroxisomes. Sterol carrier protein 2/3-oxoacyl-CoA thiolase is involved in the metabolism of 2-methyl-branched fatty acids and bile acid intermediates.从正常大鼠肝脏过氧化物酶体中纯化得到的3-氧代酰基辅酶A硫解酶A和固醇载体蛋白2/3-氧代酰基辅酶A硫解酶的底物特异性。固醇载体蛋白2/3-氧代酰基辅酶A硫解酶参与2-甲基支链脂肪酸和胆汁酸中间体的代谢。
J Biol Chem. 1997 Oct 10;272(41):26023-31. doi: 10.1074/jbc.272.41.26023.
5
Aberrant oxidation of the cholesterol side chain in bile acid synthesis of sterol carrier protein-2/sterol carrier protein-x knockout mice.在甾醇载体蛋白-2/甾醇载体蛋白-x基因敲除小鼠的胆汁酸合成中胆固醇侧链的异常氧化。
J Biol Chem. 1999 Dec 10;274(50):35455-60. doi: 10.1074/jbc.274.50.35455.
6
New insights in peroxisomal beta-oxidation. Implications for human peroxisomal disorders.过氧化物酶体β-氧化的新见解。对人类过氧化物酶体疾病的影响。
Verh K Acad Geneeskd Belg. 1998;60(3):195-214.
7
Pristanic acid beta-oxidation in peroxisomal disorders: studies in cultured human fibroblasts.
Biochim Biophys Acta. 1998 Apr 22;1391(3):351-6. doi: 10.1016/s0005-2760(98)00019-8.
8
Occurrence and possible roles of acetoacetyl-CoA thiolase and 3-ketoacyl-CoA thiolase in peroxisomes of an n-alkane-grown yeast, Candida tropicalis.乙酰乙酰辅酶A硫解酶和3-酮酰基辅酶A硫解酶在以正构烷烃生长的热带假丝酵母过氧化物酶体中的存在及可能作用
FEBS Lett. 1988 Feb 29;229(1):215-8. doi: 10.1016/0014-5793(88)80830-5.
9
Significance of catalase in peroxisomal fatty acyl-CoA beta-oxidation.过氧化氢酶在过氧化物酶体脂肪酸辅酶Aβ氧化中的意义。
Biochim Biophys Acta. 1987 Sep 4;921(1):142-50.
10
Functions and organization of peroxisomal beta-oxidation.过氧化物酶体β-氧化的功能与组织
Ann N Y Acad Sci. 1996 Dec 27;804:99-115. doi: 10.1111/j.1749-6632.1996.tb18611.x.

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Effect of Fabp1/Scp-2/Scp-x Ablation on Whole Body and Hepatic Phenotype of Phytol-Fed Male Mice.脂肪酸结合蛋白1/固醇载体蛋白-2/固醇载体蛋白-X基因敲除对植醇喂养雄性小鼠全身及肝脏表型的影响
Lipids. 2017 May;52(5):385-397. doi: 10.1007/s11745-017-4249-y. Epub 2017 Apr 5.
2
Impact of dietary phytol on lipid metabolism in SCP2/SCPX/L-FABP null mice.膳食叶绿醇对 SCP2/SCPX/L-FABP 基因敲除小鼠脂代谢的影响。
Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Mar;1862(3):291-304. doi: 10.1016/j.bbalip.2016.12.002. Epub 2016 Dec 6.
3
Structural and functional characterization of a novel gene, Hc-daf-22, from the strongylid nematode Haemonchus contortus.

本文引用的文献

1
A new peroxisomal beta-oxidation disorder in twin neonates: defective oxidation of both cerotic and pristanic acids.双胎新生儿中的一种新的过氧化物酶体β氧化障碍：神经酸和降植烷酸氧化缺陷
J Inherit Metab Dis. 1997 Sep;20(5):658-64. doi: 10.1023/a:1005318308422.
2
Sterol carrier protein X (SCPx) is a peroxisomal branched-chain beta-ketothiolase specifically reacting with 3-oxo-pristanoyl-CoA: a new, unique role for SCPx in branched-chain fatty acid metabolism in peroxisomes.固醇载体蛋白X（SCPx）是一种过氧化物酶体支链β-酮硫解酶，它特异性地与3-氧代-降植烷酰辅酶A反应：SCPx在过氧化物酶体支链脂肪酸代谢中的一种新的独特作用。
Biochem Biophys Res Commun. 1997 Jul 30;236(3):565-9. doi: 10.1006/bbrc.1997.7007.
3
来自捻转血矛线虫（Haemonchus contortus）的一个新基因Hc-daf-22的结构与功能特征
Parasit Vectors. 2016 Jul 29;9(1):422. doi: 10.1186/s13071-016-1704-1.
4
Bile acids: the role of peroxisomes.胆汁酸：过氧化物酶体的作用。
J Lipid Res. 2009 Nov;50(11):2139-47. doi: 10.1194/jlr.R900009-JLR200. Epub 2009 Apr 8.
5
Sterol carrier protein-2: new roles in regulating lipid rafts and signaling.固醇载体蛋白-2：在调节脂筏和信号传导中的新作用。
Biochim Biophys Acta. 2007 Jun;1771(6):700-18. doi: 10.1016/j.bbalip.2007.04.005. Epub 2007 Apr 12.
6
Liver fatty-acid-binding protein (L-FABP) gene ablation alters liver bile acid metabolism in male mice.肝脏脂肪酸结合蛋白（L-FABP）基因敲除改变雄性小鼠肝脏胆汁酸代谢。
Biochem J. 2005 Nov 1;391(Pt 3):549-60. doi: 10.1042/BJ20050296.
7
Characterization of a sterol carrier protein 2/3-oxoacyl-CoA thiolase from the cotton leafworm (Spodoptera littoralis): a lepidopteran mechanism closer to that in mammals than that in dipterans.棉叶夜蛾（Spodoptera littoralis）中一种固醇载体蛋白2/3-氧代酰基辅酶A硫解酶的特性：一种鳞翅目昆虫的机制，与哺乳动物的机制比双翅目昆虫的机制更为接近。
Biochem J. 2004 Aug 15;382(Pt 1):93-100. doi: 10.1042/BJ20040717.
8
Peroxisomal disorders: clinical, biochemical, and molecular aspects.过氧化物酶体疾病：临床、生化及分子层面
Neurochem Res. 1999 Apr;24(4):565-80. doi: 10.1023/a:1022592014988.
Physiological role of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein.
D-3-羟酰基辅酶A脱水酶/D-3-羟酰基辅酶A脱氢酶双功能蛋白的生理作用。
J Biochem. 1997 Mar;121(3):506-13. doi: 10.1093/oxfordjournals.jbchem.a021615.
4
Pre- and postnatal diagnosis of peroxisomal disorders using stable-isotope dilution gas chromatography--mass spectrometry.使用稳定同位素稀释气相色谱 - 质谱法进行过氧化物酶体疾病的产前和产后诊断。
J Inherit Metab Dis. 1995;18 Suppl 1:45-60. doi: 10.1007/BF00711428.
5
The reactions catalyzed by the inducible bifunctional enzyme of rat liver peroxisomes cannot lead to the formation of bile acids.大鼠肝脏过氧化物酶体的诱导型双功能酶所催化的反应不会导致胆汁酸的形成。
Biochem Biophys Res Commun. 1996 Apr 16;221(2):271-8. doi: 10.1006/bbrc.1996.0585.
6
Sterol carrier protein X is peroxisomal 3-oxoacyl coenzyme A thiolase with intrinsic sterol carrier and lipid transfer activity.固醇载体蛋白X是一种过氧化物酶体3-氧代酰基辅酶A硫解酶，具有固有的固醇载体和脂质转运活性。
J Biol Chem. 1994 Aug 19;269(33):21277-83.
7
Peroxisomal disorders: a review.过氧化物酶体疾病：综述
J Neuropathol Exp Neurol. 1995 Sep;54(5):726-39. doi: 10.1097/00005072-199509000-00016.
8
The presence of a new 3-oxoacyl-CoA thiolase in rat liver peroxisomes.大鼠肝脏过氧化物酶体中一种新型3-氧代酰基辅酶A硫解酶的存在。
Eur J Biochem. 1980 Feb;103(3):589-96. doi: 10.1111/j.1432-1033.1980.tb05984.x.