Fabre N, Brefel C, Sabatini U, Celsis P, Montastruc J L, Chollet F, Rascol O
National Institute of Health and Medical Research, INSERM U 455, Department of Neurology, Toulouse, France.
Mov Disord. 1998 Jul;13(4):677-83. doi: 10.1002/mds.870130412.
We have studied the frontal perfusion in the resting condition of two groups of patients with frozen gait: 10 patients with the syndrome of "isolated gait ignition failure" (IGIF) and 8 patients with idiopathic Parkinson's disease (PD) and severe "off" freezing. These patients were compared with two other groups: one including 20 age-matched volunteers as normal control subjects and the other one including 12 patients with progressive supranuclear palsy (PSP) as a positive control with expected frontal hypoperfusion. Frontal perfusion was assessed using single photon emission computed tomography (SPECT) regional cerebral blood flow measurement with intravenous 133Xenon. A significant frontal hypoperfusion was only present in the PSP group but not in the three others. These results do not support the hypothesis that start hesitations and freezing when walking are related to a frontal lobe dysfunction. However, it is possible that frontal neuronal dysfunction occurs without measurable cerebral blood flow changes in the resting condition.
10例“孤立性步态启动失败”（IGIF）综合征患者和8例特发性帕金森病（PD）且严重“关期”冻结的患者。将这些患者与另外两组进行比较：一组是20名年龄匹配的志愿者作为正常对照受试者，另一组是12例进行性核上性麻痹（PSP）患者作为预期存在额叶灌注不足的阳性对照。使用静脉注射133氙的单光子发射计算机断层扫描（SPECT）区域脑血流测量来评估额叶灌注。显著的额叶灌注不足仅出现在PSP组，其他三组均未出现。这些结果不支持步行时起始犹豫和冻结与额叶功能障碍有关的假说。然而，在静息状态下，额叶神经元功能障碍可能在没有可测量的脑血流变化的情况下发生。
