Lyons K E, Pahwa R, Busenbark K L, Tröster A I, Wilkinson S, Koller W C
Department of Neurology, University of Kansas Medical Center, Kansas City 66160-7314, USA.
Mov Disord. 1998 Jul;13(4):690-2. doi: 10.1002/mds.870130414.
Deep brain stimulation (DBS) of the thalamus reduces tremor in patients with essential tremor (ET). However, few studies have determined the degree of improvement in daily functioning associated with DBS. We developed a self-report Tremor Activities of Daily Living Scale (TADLS) to compare daily functioning with the stimulator turned on and off. Patients rated their performance on the 30 items of the TADLS with the stimulator turned off and then on. They also performed 10 activities under the supervision of a clinician who rated their functional ability with stimulation off and then on. There was a 58% improvement in self-rated TADLS scores in patients with DBS with the stimulator on compared with stimulation off. When activities were rated by the clinician, the average improvement in functioning with the stimulator on was 54%. There were reasonably high correlations between patient and clinician ratings of functioning. ET patients have a marked improvement in daily functioning with thalamic DBS.
丘脑深部脑刺激术（DBS）可减轻特发性震颤（ET）患者的震颤。然而，很少有研究确定与DBS相关的日常功能改善程度。我们开发了一种自我报告的日常生活震颤活动量表（TADLS），以比较刺激器开启和关闭时的日常功能。患者在刺激器关闭和开启的情况下对TADLS的30个项目进行表现评分。他们还在临床医生的监督下进行了10项活动，临床医生在刺激关闭和开启的情况下对他们的功能能力进行评分。与刺激关闭相比，刺激器开启时DBS患者的自我评定TADLS评分提高了58%。当由临床医生对活动进行评分时，刺激器开启时功能的平均改善率为54%。患者和临床医生对功能的评分之间存在相当高的相关性。ET患者通过丘脑DBS在日常功能方面有显著改善。
