Hariz G-M, Blomstedt P, Koskinen L-O D
Department of Community Medicine and Rehabilitation, Section of Occupational Therapy, Umeå University, Sweden.
Acta Neurol Scand. 2008 Dec;118(6):387-94. doi: 10.1111/j.1600-0404.2008.01065.x. Epub 2008 Jul 8.
To report long-term effects of thalamic deep brain stimulation (DBS) on activities of daily living (ADL) and health-related quality of life (HRQoL) in patients with essential tremor (ET).
Nineteen consecutive patients were evaluated at baseline, at a mean of 1 year, then at a mean of 7 years after DBS using Tremor Rating Scale, Mini Mental Test, ADL Taxonomy, Nottingham Health Profile, Life Satisfaction Checklist, Visual Analogue Scale and interview.
There was a decrease of DBS efficacy on tremor between 1 and 7 years post-operatively. The marked improvement in ADL at 1 year was no longer sustained at long-term, except for the ability to eat. Social life remained improved.
Although there is a decrease of DBS effect on tremor at 7 years, and even though further ageing and co-morbidities may impact on the well-being of patients, there is still relevant benefit of DBS on few aspects of ADL and HRQoL in patients with ET.
报告丘脑深部脑刺激术（DBS）对特发性震颤（ET）患者日常生活活动（ADL）及健康相关生活质量（HRQoL）的长期影响。
连续纳入19例患者，于基线期、平均术后1年及平均术后7年进行评估，评估工具包括震颤评分量表、简易精神状态检查、ADL分类法、诺丁汉健康量表、生活满意度清单、视觉模拟量表及访谈。
术后1至7年，DBS对震颤的疗效下降。除进食能力外，术后1年时ADL的显著改善在长期随访中未持续。社交生活仍保持改善。
尽管术后7年DBS对震颤的效果有所下降，且进一步的衰老和合并症可能影响患者的健康状况，但DBS对ET患者ADL和HRQoL的几个方面仍有显著益处。
